Cell death by self-eating: Autophagy-dependent tissue removal

自噬导致的细胞死亡：自噬依赖性组织去除

• 批准号: DP170100623
• 负责人: Prof Sharad Kumar
• 金额: $ 28.34万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-13 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100623
• 关键词: Cell; death; self; eating; Autophagy

This project aims to study the mechanisms and regulation of autophagy-dependent cell death. Cell death maintains cell and tissue homeostasis. Although most cell death is mediated by apoptosis, other modes of cell deletion have emerged recently. One form of cell death involves autophagy, the catabolic process of cellular self-digestion through lysosomal enzymes. As autophagy is a default mechanism of cell survival under stress, the idea of autophagy-dependent cell death has been controversial. This proposal aims to resolve this question and provide highly topical knowledge of broad biological significance.

本项目旨在研究自噬依赖性细胞死亡的机制和调控。细胞死亡维持细胞和组织的稳态。虽然大多数细胞死亡是由凋亡介导的，但最近出现了其他细胞缺失模式。细胞死亡的一种形式涉及自噬，即细胞通过溶酶体酶自我消化的分解代谢过程。由于自噬是细胞在压力下存活的默认机制，因此自噬依赖性细胞死亡的想法一直存在争议。该提案旨在解决这一问题，并提供具有广泛生物学意义的高度专题知识。