Autophagy and growth signalling in developmentally programmed cell death

发育性程序性细胞死亡中的自噬和生长信号传导

• 批准号: nhmrc : 1041807
• 负责人: Prof Sharad Kumar
• 金额: $ 39.62万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/autophagy-growth-signalling-cell-death/111396
• 关键词: Autophagy; growth; signalling; developmentally; programmed

Cell death is essential for normal development and deregulated cell death results in many diseases. We have recently discovered a potentially novel mechanism of developmental cell death that involves autophagy (a type of self-degradation). Our studies will now examine the mechanism of autophagic cell death and study how cell growth regulation is integrated in this pathway. This will provide us important knowledge into the complex role of autophagy in cancer.

细胞死亡是正常发育的必要条件，细胞死亡失控导致许多疾病。我们最近发现了一种潜在的新的发育细胞死亡机制，涉及自噬（一种自我降解）。我们现在的研究将探讨自噬细胞死亡的机制，并研究细胞生长调节如何在这一途径中整合。这将为我们了解自噬在癌症中的复杂作用提供重要的知识。