Characterisation of the tumour suppressor function of caspase-2
Characterisation of the tumour suppressor function of caspase-2
批准号:
nhmrc : 626905
负责人:
Prof Sharad Kumar
金额:
$40.35万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Aberrant cell death (apoptosis) is associated with many diseases including cancer. Apoptosis is mediated by a group of enzymes called caspases. Recently we have discovered that one of these enzymes, caspase-2, acts as a tumour suppressor. We now wish to validate this finding in several preclinical models of cancer and understand precisely how caspase-2 works to safeguard cells against cancer development. These studies will help better understand cancer and ways to treat it.
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依托单位:
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国内基金
海外基金
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依托单位: