Mechanisms of interferon induction by hepatitis D virus and impact of chronic innate immune activation on antiviral immunity (08)

慢性病毒感染可调节先天免疫系统的持续激活，并导致免疫反应功能障碍。慢性病毒性肝炎患者干扰素信号的激活不仅与病情加重有关，而且与肝移植患者接受器官的良好预后有关。该项目的目的是建立慢性HDV感染的模型，该模型通过尚不清楚的机制诱导先天性免疫。我们将定义参与HDV感染的先天感知和信号通路，并破译体外和体内慢性先天免疫激活对细胞免疫的功能后果。

Chronic virus infections can mediate persistent activation of the innate immune system and result in a dysfunctional immune response. The activation of interferon signaling in chronic viral hepatitis correlates with more severe disease, but also with a favorable prognosis of organ acceptance in the setting of liver transplantation. The aim of this project is to establish models of chronic HDV infection that induces innate immunity by yet poorly understood mechanisms. We will define the innate sensing and signaling pathways that are engaged upon HDV infection and decipher the functional consequences of chronic innate immune activation on cellular immunity in vitro and in vivo.