新規ナノ多孔性金属電極を用いた携帯型電気化学癌診断プラットフォームの構築

使用新型纳米多孔金属电极构建便携式电化学癌症诊断平台

• 批准号: 21F20039
• 负责人: 山内 悠輔
• 金额: $ 1.47万
• 依托单位: National Institute for Materials Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-09-28 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21F20039/
• 关键词: 多孔体

The goal of this project was to develop an inexpensive, portable and automated system for rapid disease diagnosis by using novel metal nanoarchitectures.These projects are:a.　Hydrogel integrated mesoporous gold chronocoulometric sensor for ultrasensitive detection of miRNA.- We fabricated mesoporous gold and integrated it with the hydrogel chemistry to harness the best intrinsic activity from the system to apply for microRNA sensing. The developed sensor provided a much easy, reusable, and highly sensitive microRNA sensor.b. Nanoarchitectured superparamagnetic iron oxide-doped mesoporous carbon nanozymes for biosensing.- We developed a superparamagnetic nano-enzyme that showed high potentiality for magnetic isolation and purification as well as nano-enzyme activity.

该项目的目标是通过使用新型金属纳米结构来开发用于快速疾病诊断的廉价、便携式和自动化系统。水凝胶集成介孔金计时库仑传感器用于miRNA的超灵敏检测。我们制造了介孔金，并将其与水凝胶化学相结合，以利用系统的最佳内在活性来应用于microRNA传感。所开发的传感器提供了一种非常简单、可重复使用且高度灵敏的microRNA传感器。纳米结构的超顺磁性氧化铁掺杂的中孔碳纳米酶用于生物传感。我们开发了一种超顺磁性纳米酶，显示出高潜力的磁分离和纯化以及纳米酶的活性。

项目成果

κ-Carrageenan Gel Modified Mesoporous Gold Chronocoulometric Sensor for Ultrasensitive Detection of MicroRNA

κ-卡拉胶凝胶修饰介孔金计时库仑传感器用于超灵敏检测 MicroRNA

• DOI: 10.1246/bcsj.20210286
• 发表时间: 2022
• 期刊: Bulletin of the Chemical Society of Japan
• 影响因子: 4
• 作者: Salahuddin Bidita;Masud Mostafa Kamal;Aziz Shazed;Liu Chia-Hung;Amiralian Nasim;Ashok Aditya;Hossain S. M. Azad;Park Hyeongyu;Wahab Md Abdul;Amin Mohammed A.;Chari M. Adharvana;Rowan Alan E.;Yamauchi Yusuke;Hossain Md. Shahriar A.;Kaneti Yusuf Valentino
• 通讯作者: Kaneti Yusuf Valentino

Nanoarchitectured Superparamagnetic Iron Oxide-Doped Mesoporous Carbon Nanozymes for Glucose Sensing

• DOI: 10.1016/j.snb.2022.131980
• 发表时间: 2022-04
• 期刊: Sensors and Actuators B: Chemical
• 作者: M. A. Wahab;S. Hossain;M. Masud;H. Park;Aditya Ashok;M. Mustapić;Minjun Kim;D. Patel;M. Shahb