若年期の摂食制限の記憶がもつ成年期の摂食行動における役割

童年早期饮食限制的记忆对成年饮食行为的作用

• 批准号: 21F21082
• 负责人: McHugh Thomas
• 金额: $ 1.47万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-28 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21F21082/
• 关键词: hippocampus; hypothalmus; feeding; learning; context; hunger; memory

Over the last fiscal year, we have made significant progress in our understanding of the neural circuit from subiculum in hippocampus to arcuate nucleus in hypothalamus. Using a virus combination of CRE recombinase and FLP recombinase, we observed the labelling cells in the subiculum. We have also employed viral-based manipulation methods to investigate the role of this circuit in both feeding and learning components. Meanwhile, the behavior paradigm also confirmed that the internal state of animals (hunger or satiety) could be a context for adaptive behaviors. These findings have important implications for our understanding of neural circuits involved in feeding and learning and may pave the way for targeted therapies for related disorders.

在过去的一年中，我们对海马体下托到下丘脑弓状核的神经回路的理解取得了重大进展。利用CRE重组酶和FLP重组酶的病毒组合，我们观察了耻骨下的标记细胞。我们还采用基于病毒的操作方法来研究该电路在喂养和学习组件中的作用。同时，行为范式也证实了动物的内部状态（饥饿或饱腹）可能是适应行为的背景。这些发现对我们理解与进食和学习有关的神经回路具有重要意义，并可能为相关疾病的靶向治疗铺平道路。