記憶プロセスにおける海馬CA2野の動態の解明

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The last fiscal year focused on addressing the anatomical connectome of CA2 using viral tracing methods. To map the brain-wide connections, several transgenic mouse lines were applied, along with an unsupervised machine learning approach to reveal divergent phenotypes, especially highlighting the hippocampal-medial septum circuits. These results help to lay the foundation for designing behavioral experiments. Meanwhile, to dissect the physiological features of CA2 during memory information routing, analysis at the single-cell and population level revealed a novel role for CA2 in mediating hippocampal dynamics under discrete behavioral states. Such results were also compared and reviewed with previous works to suggest a unique role of CA2 during memory processing.