記憶プロセスにおける海馬CA2野の動態の解明

上一财年的重点是利用病毒追踪方法解决CA2的解剖连接体。为了绘制全脑连接图，研究人员使用了几种转基因小鼠系，并使用无监督机器学习方法来揭示不同的表型，特别是突出海马-内侧隔膜回路。这些结果有助于为设计行为实验奠定基础。同时，为了剖析CA2在记忆信息传递过程中的生理特征，在单细胞和群体水平上的分析揭示了CA2在离散行为状态下介导海马动力学的新作用。这些结果也与以前的工作进行了比较和回顾，以表明CA2在记忆加工中的独特作用。

The last fiscal year focused on addressing the anatomical connectome of CA2 using viral tracing methods. To map the brain-wide connections, several transgenic mouse lines were applied, along with an unsupervised machine learning approach to reveal divergent phenotypes, especially highlighting the hippocampal-medial septum circuits. These results help to lay the foundation for designing behavioral experiments. Meanwhile, to dissect the physiological features of CA2 during memory information routing, analysis at the single-cell and population level revealed a novel role for CA2 in mediating hippocampal dynamics under discrete behavioral states. Such results were also compared and reviewed with previous works to suggest a unique role of CA2 during memory processing.