Elucidating the Dynamics of Memory

阐明记忆的动态

• 批准号: 19H05646
• 负责人: McHugh Thomas
• 金额: $ 106.41万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-06-26 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H05646/
• 关键词: hippocampus; cortex; oscillations; memory; engram; phyiology; consolidation; Memory; Hippocampus; Oscillations; Physiology

During the previous fiscal year we have continued to conducted experiments investigating how oscillations and spiking organize the precise activity of subsets of neurons related to memory and experience. We published a manuscript detailing a state-dependent impact of transient silencing of the CA2 subfield of the hippocampus on the dynamics of network activity in the structure, featuring our newly developed machine learning based algorithm for the decoding of position based on the spikes recorded on a single tetrode. This allowed us, for the first time, to look at positional decoding in a subfield and state dependent manner. We have also published a review paper on our previous work on the differential contributions of the CA2 and CA3 subfields to sharp-wave ripples and replay. We have collected data using closed-loop optogenetics and using high-density neuropixels recording that will be analyzed in the coming fiscal year.

在上一个财政年度，我们继续进行实验，研究振荡和尖峰是如何组织与记忆和经验相关的神经元子集的精确活动的。我们发表了一篇手稿，详细介绍了海马体CA2子场的短暂沉默对结构中网络活动动态的状态依赖性影响，其中包括我们新开发的基于机器学习的算法，该算法基于在单个四极体上记录的尖峰解码位置。这使我们第一次能够以子字段和状态依赖的方式查看位置解码。我们还发表了一篇综述论文，回顾了我们之前关于CA2和CA3子场对锐波涟漪和重放的差异贡献的工作。我们使用闭环光遗传学和高密度神经像素记录收集数据，将在下一个财政年度进行分析。

项目成果

engrams, inhibition and oscillaitons

印迹、抑制和振荡

• 发表时间: 2022
• 作者: Abe Mitsuhiro;Makino Asami;Murate Motohide;Hullin-Matsuda Francoise;Yanagawa Masataka;Sako Yasushi;Kobayashi Toshihide;Thomas McHugh
• 通讯作者: Thomas McHugh

The expanded circuitry of hippocampal ripples and replay

海马波纹和重放的扩展电路

• DOI: 10.1016/j.neures.2022.12.010
• 发表时间: 2023
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: He Hongshen;Guan Hefei;McHugh Thomas J.
• 通讯作者: McHugh Thomas J.

memory modulation by noncanonical hippocampal-subcortical circuits

非典型海马皮层下回路的记忆调节

• 发表时间: 2020
• 作者: 伊藤青葉;香川裕之;成田勝;長田穣;水産;近藤倫生;Thomas McHugh
• 通讯作者: Thomas McHugh

Inst. of Psych.&Neurosci. of Paris/Universite de Paris/Paris Psychiatrie and Neurosciences(フランス)

巴黎精神病学与神经科学学院/巴黎精神病学与神经科学学院（法国）

CA2 circuit mediating hippocampal modulation of cholinergic tone

CA2 回路介导海马胆碱能调节

• 发表时间: 2022
• 作者: 松本 健;黒川 留美;凌 楓;鈴木 健裕;堂前 直;吉田 稔;山口 芳樹;村上弘章・笹野祥愛・益田玲爾・笠井亮秀・山下洋;Thomas McHugh
• 通讯作者: Thomas McHugh