Lysine acylation in cellular regulation, ageing and disease

赖氨酸酰化在细胞调节、衰老和疾病中的作用

• 批准号: 318191341
• 负责人: Professor Dr. Michael Lammers
• 金额: --
• 依托单位: Institut für Biochemie
• 依托单位国家: 德国
• 项目类别: Heisenberg Fellowships
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/318191341?language=en
• 关键词: Lysine; acylation; cellular; regulation; ageing

The precondition for a Heisenberg Programme funding is high scientific quality and originality of the research project at international level and suitability for further qualification as a university teacher. Applicants need to meet all the requirements for appointment to a permanent professorship.The aim of this programme is to enable outstanding scientists to prepare for a scientific leadership function, and simultaneously work on further research topics. This research does not necessarily need to be planned and carried out in the form of a project.For this reason, and unlike the procedure in other funding programmes, both the abstracts of applications and final reports are not required and will therefore not be published in GEPRIS.

海森堡计划资助的先决条件是高科学质量和国际水平的研究项目的原创性，并适合作为大学教师的进一步资格。申请人需要满足任命为永久教授的所有要求。该计划的目的是使杰出的科学家为科学领导职能做好准备，同时从事进一步的研究课题。这项研究并不一定需要以项目形式规划和进行，因此，与其他资助计划的程序不同，申请摘要和最后报告都不需要，因此不会在GEPRIS上发表。

项目成果

A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation*

KRAS GTPase K104Q 突变体通过抵消调节缺陷来保留下游信号传导*

• DOI: 10.1074/jbc.m116.762435
• 发表时间: 2017
• 期刊: The Journal of Biological Chemistry
• 作者: Kistler S;George S.D;Kuhlmann N;Garvey L;Huynh M;Bagni R.K;Lammers M;Der C.J;Campbell S.L
• 通讯作者: Campbell S.L

Expression and Purification of Site-Specifically Lysine-Acetylated and Natively-Folded Proteins for Biophysical Investigations.

用于生物物理研究的位点特异性赖氨酸乙酰化和天然折叠蛋白的表达和纯化

• DOI: 10.1007/978-1-4939-7574-7_11
• 发表时间: 2018
• 期刊: Methods in molecular biology
• 作者: Lammers M.

Insights into K-Ras 4B regulation by post-translational lysine acetylation

• DOI: 10.1515/hsz-2016-0118
• 发表时间: 2016-10-01
• 期刊: BIOLOGICAL CHEMISTRY
• 影响因子: 3.7
• 作者: Knyphausen, Philipp;Lang, Franziska;Lammers, Michael
• 通讯作者: Lammers, Michael