Molecular signatures in pre-RA patients by multi-omics analysis

通过多组学分析获得 RA 前期患者的分子特征

• 批准号: 20H03720
• 负责人: TAKEUCHI Tsutomu
• 金额: $ 11.4万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20H03720/
• 关键词: 関節リウマチ; シングルセル解析; 自己抗体; 間質性肺炎; 自己免疫疾患; リンパ球; 抗原特異性; 抗シトルリン化タンパク質抗体; 抗翻訳後修飾蛋白抗体; 肺胞洗浄液; リウマチ因子; 寛解、分子病態、網羅的解析; 診断前継時コホート; 残存分子シグネチャー

项目成果

Association between the patterns of large-vessel lesions and treatment outcomes in patients with large-vessel giant cell arteritis

大血管巨细胞动脉炎患者大血管病变模式与治疗结果之间的关联

• DOI: 10.1093/mr/roac122
• 发表时间: 2022
• 期刊: Modern Rheumatology
• 影响因子: 2.2
• 作者: Sugihara Takahiko;Uchida Haruhito A;Yoshifuji Hajime;Maejima Yasuhiro;Naniwa Taio;Katsumata Yasuhiro;Okazaki Takahiro;Ishizaki Jun;Murakawa Yohko;Ogawa Noriyoshi;Dobashi Hiroaki;Horita Tetsuya;Tanaka Yoshiya;Furuta Shunsuke;Takeuchi Tsutomu;Komagata Yoshi
• 通讯作者: Komagata Yoshi

Impact of age on the efficacy and safety of peficitinib (ASP015K) for the treatment of rheumatoid arthritis

年龄对培菲替尼（ASP015K）治疗类风湿关节炎疗效和安全性的影响

• DOI: 10.1093/mr/roab058
• 发表时间: 2022
• 期刊: Modern Rheumatology
• 影响因子: 2.2
• 作者: Tanaka Yoshiya;Takeuchi Tsutomu;Kato Daisuke;Kaneko Yuichiro;Fukuda Musashi;Miyatake Daisuke
• 通讯作者: Miyatake Daisuke

Lupus low disease activity state within 12 months is associated with favourable outcomes in severely active systemic lupus erythematosus

12 个月内狼疮低疾病活动状态与严重活动性系统性红斑狼疮的良好结局相关

• DOI: 10.1093/rheumatology/keac002
• 发表时间: 2022
• 期刊: Rheumatology
• 影响因子: 5.5
• 作者: Kikuchi Jun;Hanaoka Hironari;Saito Shuntaro;Oshige Tatsuhiro;Hiramoto Kazuoto;Kaneko Yuko;Takeuchi Tsutomu
• 通讯作者: Takeuchi Tsutomu

Efficacy and safety of abatacept in biologic-naive patients with active rheumatoid arthritis by background methotrexate dose: <i>post hoc</i> analysis of a randomized, placebo-controlled, phase 4 study

根据背景甲氨蝶呤剂量，阿巴西普对未接受过生物制剂治疗的活动性类风湿性关节炎患者的疗效和安全性：随机、安慰剂对照、4 期研究的事后分析

• DOI: 10.1093/mr/roab029
• 发表时间: 2022
• 期刊: Modern Rheumatology
• 影响因子: 2.2
• 作者: Tanaka Yoshiya;Matsubara Tsukasa;Hashizume Koichi;Amano Norihito;Takeuchi Tsutomu
• 通讯作者: Takeuchi Tsutomu

Serum cytokines and bone metabolic markers in patients with rheumatoid arthritis treated with biological disease modifying anti-rheumatic drugs

• DOI: 10.1007/s10067-022-06390-x
• 发表时间: 2022-09-26
• 期刊: CLINICAL RHEUMATOLOGY
• 影响因子: 3.4
• 作者: Tamai, Hiroya;Nishina, Naoshi;Kaneko, Yuko
• 通讯作者: Kaneko, Yuko