Identification and characterization of pathogenesis related molecules in early rheumatoid arthritis by DNA microarray
Identification and characterization of pathogenesis related molecules in early rheumatoid arthritis by DNA microarray
批准号:
23390259
负责人:
TAKEUCHI Tsutomu
金额:
$12.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
To elucidate superior key molecules on the pathogenesis of rheumatoid arthritis (RA), we comprehensively analyzed peripheral blood gene expression in RA patients by DNA microarray. We confirmed characteristic changes of gene expression in RA and identified Family with sequence similarity 20, member A (FAM20A) as a most related gene with disease activity. It was confirmed this could reflect drug effects. Further optimization and contribution to the pathogenesis should be investigated.
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RAの治療:新しい生物学的製剤治療抵抗性関節リウマチに対するゴリムマブ(GLM:ヒト抗TNFαモノクローナル抗体)単剤療法:52週までの有効性/安全性の解析結果ワークショップ11
RA 治疗:戈利木单抗(GLM:人抗 TNFα 单克隆抗体)单一疗法治疗新生物治疗耐药的类风湿性关节炎:长达 52 周的疗效/安全性分析结果研讨会 11
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[K. Tanegashima, K. Suzuki, Y. Nakayama, K. Tsuji, A. Shigenaga, A. Otaka, and T. Hara, 竹内勤]
通讯作者:
竹内勤
CD3 Zeta Defects in Systemic Lupus Erythematosus.
系统性红斑狼疮中的 CD3 Zeta 缺陷。
DOI:
--
发表时间:
2012
期刊:
Ann Rheum Dis
影响因子:
27.4
作者:
[矢持忠徳, 守田陽平, 矢持淑子, Sanaz Firouzi, 佐々木陽介, 渡辺信和, 内丸薫, 宇都宮與, 渡邉俊樹, Takeuchi Takeuchi]
通讯作者:
Takeuchi Takeuchi
Efficacy of tocilizumab for rheumatoid arthritis patients in daily practice in Japan-message from REACTION study
日本日常实践中托珠单抗对类风湿性关节炎患者的疗效——来自 REACTION 研究的信息
DOI:
--
发表时间:
2011
期刊:
Modern Rheum
影响因子:
--
作者:
[Yamanaka H, Tanaka Y, Inoue E, Hoshi D, Momohara S, Hanami K, Yunoue N, Saito K, Amano K, Kameda H, Takeuchi T]
通讯作者:
Takeuchi T
DOI:
10.3899/jrheum.110014
发表时间:
2011-08-01
期刊:
JOURNAL OF RHEUMATOLOGY
影响因子:
3.9
作者:
[Kameda, Hideto, Kanbe, Katsuaki, Takeuchi, Tsutomu]
通讯作者:
Takeuchi, Tsutomu
Application of transcriptomics for systemic lupus erythematosus pathogenesis analysis
转录组学在系统性红斑狼疮发病机制分析中的应用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[鈴木勝也, 竹内勤]
通讯作者:
竹内勤
共 30 条
Molecular signatures in pre-RA patients by multi-omics analysis
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Construction of a galaxy SED model consistent with chemical evolution
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Performance and System Analyses on Indoor Broadband Multimedia Wireless Communication System
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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Molecular mechanism and its regulation of heterophilic adhesion between α E 3 7 (CD103) and E-cadherin in autoimmune epithelial injury
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批准号:18591122
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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The analyses on indoor wireless environments and the transmission performance of giga-bit wireless LAN
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Biological, Epidemiological and Clinical Studies on Amebic Infection among Institutionalized Populations
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Research that factor and morbid state, of Congenital Chagas disease in South America
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International Collaborative Studies on the Control of Soil-Transmitted Helminthiases and Schostosomiasis
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Realization of next generation multimedia PHS system
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全身性エリテマトーデス患者T細胞に発現されるTCRζ鎖の異常に関する研究
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Role of alphaEbeta7 on tissue destruction of autoimmune diseases
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STUDY OF CONGENITAL CHAGAS' DISEASE
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Cell Biological, Epidemiological and Clinical Studies on Entamoeba dispar infection
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A High-speed Indoor Wireless Communication System Employing an Anti-multipath Modulation Scheme
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资助金额:$4.29万
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负责人:TAKEUCHI Tsutomu
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Study on signal transduction pathway via integrins in autoimmune T cells
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批准号:07670539
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资助金额:$1.54万
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Biological and Clinical Studies on the Differnece between Pathogenic and Nonpathogenic Entamoeba histolytica
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负责人:TAKEUCHI Tsutomu
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Structure of upregulated VLA-4 antigen expressed on PBL from SLE
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负责人:TAKEUCHI Tsutomu
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海外基金