Three dimensional mapping of turbid media by hyper spectral imaging

通过高光谱成像对浑浊介质进行三维绘图

• 批准号: 337270237
• 负责人: Professor Dr.-Ing. Michael Schmidt
• 金额: --
• 依托单位: Lehrstuhl für Photonische Technologien (LPT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/337270237?language=en
• 关键词: Three; dimensional; mapping; turbid; media

Non-invasive modalities in medical imaging diagnostics are of vital importance in order to minimize the risks for patients, particularly since many diseases necessitate repetitive imaging. Furthermore, preventing high costs from impeding regular examinations, fast and cost-efficient imaging modalities are needed. Ideally, these methods should also enable label free imaging, as labels bear potential side effects for the patients such as allergies. Furthermore, the development of suitable markers is a costly and time-consuming process. Hyperspectral imaging systems have the potential to enable fast, low-cost, non-invasive and label free imaging. Thus, they provide the opportunity to overcome all the mentioned challenges. Therefore, the goal of the planned research project is to compile and to investigate methods for the transformation of hyperspectral images into three-dimensional tissue images. Two mechanisms leading to a wavelength dependency of the penetration depth in tissue will be used for this: the wavelength dependent absorption in tissue constituents such as hemoglobin and water as well the wavelength dependent scattering behavior of the tissue. Within the scope of this project different transformation approaches are investigated and evaluated. As outcome, an optical non-invasive modality for the examination of malign near-surface tissue alterations is expected which also provides the doctor with a large field of view.Compared to established optical 3D reconstruction methods such as Optical Coherence Tomography, the new approach has the advantage of not only measuring and analyzing changes in refractive index and scattering, but also changes in absorptivity. Therefore, absorber concentration changes, such as the amount of blood in cancerous and healthy tissue or scattering concentration changes, this means the amount of scatterers in blood vessel and surrounding tissue, should be detectable. This combination of the detectability of scattering and absorber alterations and the reconstruction of the in-depth resolved images promises improved detection of malign subsurface alterations. The detection is simplified by the fact that the images of a specific depth are not convoluted with all other depths anymore. This should increase the contrast significantly and it should enable a more reliable diagnosis since possible disguises of tissue alterations are removed. Furthermore, since the imaging approach is contact free and uses standard white light sources for illumination, it will enable low-risk and inexpensive repetitive examinations of patients.

医学影像诊断中的非侵入性方式对于将患者的风险降至最低至关重要，特别是在许多疾病需要重复成像的情况下。此外，为了防止高昂的费用阻碍常规检查，需要快速和具有成本效益的成像方式。理想情况下，这些方法还应该实现无标记成像，因为标记对患者有潜在的副作用，如过敏。此外，开发合适的标记是一个昂贵和耗时的过程。高光谱成像系统有可能实现快速、低成本、非侵入性和无标记成像。因此，它们提供了克服所有上述挑战的机会。因此，计划中的研究项目的目标是汇编和研究将高光谱图像转换为三维组织图像的方法。将使用两种机制导致组织中穿透深度的波长依赖性：组织成分(如血红蛋白和水)中的波长依赖性吸收以及组织的波长依赖性散射行为。在该项目的范围内，对不同的转换方法进行了调查和评估。与现有的光学三维重建方法(如光学相干层析成像)相比，新方法不仅可以测量和分析折射率和散射的变化，而且还可以测量和分析吸收率的变化。因此，吸收体浓度的变化，如癌变组织和健康组织中的血液量或散射浓度的变化，这意味着血管和周围组织中的散射体的数量，应该是可检测的。这种散射和吸收层变化的可探测性和深度分辨率图像的重建相结合，保证了对恶性地下变化的更好检测。由于特定深度的图像不再与所有其他深度的图像卷积，检测被简化了。这应该会显著增加对比度，而且它应该能够实现更可靠的诊断，因为可能的组织变化伪装被去除了。此外，由于成像方法是无接触的，并使用标准白光源照明，它将使患者能够进行低风险和廉价的重复检查。