Micro-scale geometrically and metallurgically adapted surface structures of implants for the defined stimulation of the osteogenic differentiation

微尺度几何和冶金适应的植入物表面结构，用于明确刺激成骨分化

• 批准号: 341161542
• 负责人: Professor Dr.-Ing. Horst Fischer
• 金额: --
• 依托单位: Institut für Schweißtechnik und Fügetechnik (ISF)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/341161542?language=en
• 关键词: Micro; scale; geometrically; metallurgically; adapted

Metal implants for orthopedic applications have been in use for a long time. Improvements of the osseointegration behavior by surface-changing processes, such as sand blasting or etching, were so far only obtained in empirical studies. It is not yet completely understood which surface chemistry and structure can support the initial cell-implant response. This interdisciplinary research project has the aim to systematically investigate the specific mechanisms of the cellular response to (metallurgically changed) surfaces which were subjected to defined microstructures by the electron beam and alloyed up/leached with filler material. Particularly interesting is the alloying up of pure titanium on Ti6Al4V-substrates in a locally selective manner. In doing so, the response of bone-forming cells on the microstructures shall be investigated in vitro qualitatively and quantitatively and the correlation of the type of microstructuring and alloy shall be analyzed. Further, it shall be investigated how the known structuring process 'SurfiSculpt' - expanded by the simultaneous changeability of the chemical composition of the surface - can be transferred to the micro-scale dimension. Particularly the local alloy composition of the microstructured surface is investigated so that the differentiation behavior of human mesenchymal stem cells to bone-forming cells can be controlled. Research results will be additional knowledge about the cellular response on metal surfaces and the determination of the positive effect of geometrical and metallurgical surface modifications on implants.

用于骨科应用的金属植入物已经使用了很长时间了。到目前为止，仅在经验研究中才能获得通过改变表面的过程（例如砂爆或蚀刻）来改善骨整合行为。尚不完全了解哪种表面化学和结构可以支持初始的细胞植入剂反应。该跨学科研究项目的目的是系统地研究细胞反应（冶金变化）表面的特定机制，该表面受电子束对定义的微结构进行，并与填充物材料合金/浸出。特别有趣的是，以当地选择性的方式将纯钛合成在Ti6al4v-substrates上。这样，应在定性和定量上进行体外研究骨形成细胞对微结构的反应，并应分析微结构和合金的类型的相关性。此外，应研究已知的结构过程如何通过表面化学成分的同时可变性扩展的已知结构过程可以转移到微尺度维度。特别是研究了微观结构表面的局部合金组成，因此可以控制人间充质干细胞对骨形成细胞的分化行为。研究结果将是有关金属表面上细胞反应的其他知识，并确定几何和冶金表面修饰对植入物的积极作用。