Crosstalk between peroxisomes, endoplasmic reticulum and endosomes during polar growth and development in fungi
真菌极地生长和发育过程中过氧化物酶体、内质网和内涵体之间的串扰
基本信息
- 批准号:351340304
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2017
- 资助国家:德国
- 起止时间:2016-12-31 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cell organelles like peroxisomes, the endoplasmic reticulum (ER) and endosomes have long been considered as confined compartments with distinct isolated functions. Peroxisomes participate in primary and secondary metabolism as well as in Reactive Oxygen Species (ROS) signaling, whereas endosomes serve as multipurpose platforms for long distance transport of macromolecules. However, recent advances show that organelles are rather dynamic structures that heavily interact with each other. For example, a close molecular link between peroxisomes and endosomes was established in fungal cells by showing that microtubule-dependent transport of early endosomes distributes peroxisomes throughout hyphae. In addition, lipid droplets (LDs) and ER segments are transported by these endosomes. At the same time, the formation and dynamics of LDs, endosomes, and peroxisomes depend on the ER. Remarkably, mRNAs encoding septins are an additional important cargo for early endosomes. Experimental data support a model in which local translation of septin mRNAs at the cytoplasmic surface of endosomes promotes septin oligomer assembly and formation of higher-order structures. Here, we propose to investigate (i) the biological function of peroxisomes during polar growth and development, (ii) a potential functional link between mRNA transport and the crosstalk of peroxisomes, ER and endosomes. To provide a broad view on these aspects our team consists of fungal biology experts using established model systems such as Ustilago maydis, Aspergillus nidulans, Neurospora crassa and Podospora anserina. Genetic, biochemical and cell biological approaches will be combined to identify molecular mechanisms and essential components in organelle dynamics. By comparing the crosstalk between organelles in different fungal models, we will uncover fundamental, evolutionary conserved processes, as well as specific mechanisms adapted to the life styles of different fungi. Obtained results will be of general interest for cell biologists and the gained knowledge can be applied to improve the production of secondary metabolites and to develop novel fungicides.
过氧化物酶体、内质网和核内体等细胞器一直被认为是具有不同功能的封闭区室。过氧化物酶体参与初级和次级代谢以及活性氧(ROS)信号传导,而核内体充当大分子长距离运输的多用途平台。然而,最近的进展表明,细胞器是相当动态的结构,相互之间存在密切的相互作用。例如,在真菌细胞中,过氧化物酶体和内体之间的紧密分子联系通过显示早期内体的微管依赖性运输将过氧化物酶体分布在整个菌丝中而建立。此外,脂滴(LD)和ER片段通过这些内体转运。同时,LD、内体和过氧化物酶体的形成和动力学依赖于ER。值得注意的是,编码septins的mRNA是早期内体的额外重要货物。实验数据支持这样一种模型,其中胞膜蛋白mRNA在内体的细胞质表面的局部翻译促进胞膜蛋白寡聚体组装和更高级结构的形成。在这里,我们建议调查(i)过氧化物酶体在极性生长和发育过程中的生物学功能,(ii)mRNA运输和过氧化物酶体,ER和内体的串扰之间的潜在功能联系。为了提供对这些方面的广泛看法,我们的团队由真菌生物学专家组成,使用已建立的模型系统,如玉米黑粉菌,构巢曲霉,粗糙脉孢菌和鹅柄孢菌。遗传,生物化学和细胞生物学方法将结合起来,以确定细胞器动力学的分子机制和基本组成部分。通过比较不同真菌模型中细胞器之间的串扰,我们将揭示基本的,进化保守的过程,以及适应不同真菌生活方式的特定机制。所获得的结果将是细胞生物学家的普遍兴趣,所获得的知识可以应用于提高次级代谢产物的生产和开发新的杀菌剂。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr. Michael Bölker其他文献
Professor Dr. Michael Bölker的其他文献
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{{ truncateString('Professor Dr. Michael Bölker', 18)}}的其他基金
The role of small GTPases for exocyst localization and regulation of polar growth in Ustilago maydis
小 GTP 酶在玉米黑粉菌外囊定位和极性生长调节中的作用
- 批准号:
161738410 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Research Units
Nitrogen-dependent regulation of secondary metabolism in Ustilago maydis
玉米黑粉菌次生代谢的氮依赖性调控
- 批准号:
70346709 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Research Grants
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9903325 - 财政年份:2019
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The interplay between viperin, peroxisomes and the cellular innate antiviral response
蝰蛇蛋白、过氧化物酶体和细胞先天抗病毒反应之间的相互作用
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Molecular and functional characterization of a membrane contact site between peroxisomes and the endoplasmic reticulum
过氧化物酶体与内质网之间膜接触位点的分子和功能表征
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397476530 - 财政年份:2018
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The molecular mechanism and cellular function of interaction between oil bodies and peroxisomes
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Relationship between lipid droplets and peroxisomes through the mitochondria-associated ER membrane
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An oxygen-recognition system through organelle crosstalk between the mitochondria and peroxisomes in yeast
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19780062 - 财政年份:2007
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