Development of novel therapeutic strategies targeting cellular metabolism in autoimmune diseases
Development of novel therapeutic strategies targeting cellular metabolism in autoimmune diseases
批准号:
18K08387
负责人:
Saegusa Jun
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2018
资助国家:
日本
项目状态:
已结题
起止时间:
2018-04-01 至 2021-03-31
中文摘要
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英文摘要
期刊论文(9)
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DOI:
10.1038/s41598-019-42932-1
发表时间:
2019-04-23
期刊:
SCIENTIFIC REPORTS
影响因子:
4.6
作者:
[Ueda, Yo, Saegusa, Jun, Morinobu, Akio]
通讯作者:
Morinobu, Akio
Combined inhibition of mechanistic target of rapamycin and glutamine metabolism inhibits CD4 T cell proliferation and Th17 differentiation, facilitates the expansion of myeloid-derived suppressor cells, and synergistically ameliorates arthritis in SKG mic
联合抑制雷帕霉素和谷氨酰胺代谢的机械靶标可抑制 CD4 T 细胞增殖和 Th17 分化,促进骨髓源性抑制细胞的扩增,并协同改善 SKG 小鼠的关节炎
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Ueda Y, Saegusa J, Okano T, Sendo S, Yamada H, Akashi K, Onishi A, Morinobu A]
通讯作者:
Morinobu A
DOI:
10.1186/s13075-019-1963-2
发表时间:
2019-08-06
期刊:
ARTHRITIS RESEARCH & THERAPY
影响因子:
4.9
作者:
[Sendo, Sho, Saegusa, Jun, Morinobu, Akio]
通讯作者:
Morinobu, Akio
Combination therapy of rapamycin and a glutamine antagonist facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice.
雷帕霉素和谷氨酰胺拮抗剂的联合治疗可促进 SKG 小鼠骨髓源性抑制细胞的扩增并改善关节炎。
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Ueda Y, Saegusa J, Okano T, Sendo S, Yamada H, Ichise Y, Naka I, Takahashi S, Akashi K, Onishi A, Morinobu A]
通讯作者:
Morinobu A
A metabolic approach for discovering therapeutic target in rheumatoid arthritis synovial fibroblast
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批准号:15K09525
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2015
-
负责人:Saegusa Jun
-
依托单位:
海外基金