Functional organization of posterior parietal cortex during multimodal sensory based decisions in the freely moving animal (D05*)

这个项目的中心焦点是后顶叶皮质，这是一个从初级体感和视觉皮质接受传入投射的大脑区域。它被认为参与了基于视觉信息的决策，但也参与了涉及空间导航的任务。该项目将在大鼠身上使用双光子钙离子成像和头盔微型多光子显微镜来评估PPC中神经元群体的活动，因为他们正在执行各种旨在测试PPC不同功能的行为任务。该项目将揭示PPC在导航和感官决策任务中潜在功能的神经元回路组织的一些中心原则。

The central focus of this project is the posterior parietal cortex, a brain area that receives afferent projections from primary somatosensory and visual cortices. It is thought to be involved in decision making based on visual information, but also in tasks involving spatial navigation. The project will use two-photon Ca2+ imaging with head-mounted miniaturized multiphoton microscope in rats to assess the activity of neuronal populations in the PPC, as they are performing a variety of behavioral tasks designed to test the different functions of the PPC. The project will reveal some of the central principles of organization of the neuronal circuits underlying the function of the PPC in navigational and sensory decision-making tasks.