NEUROENDOCRINE CONTROL OF PATERNAL CARE IN THE COMMON MARMOSET

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：探讨雄性绒猴父性护理质量的影响因素。 在父母教养不善或父母缺席的情况下，有许多心理社会障碍会扰乱人类健康。绒猴是为数不多的社会组织/家庭结构与人类相似的哺乳动物之一。这些研究旨在确定在表现出广泛的父母关怀的双亲男性中启动父亲关怀行为的荷尔蒙途径。嗅觉线索可以对许多哺乳动物物种产生启动作用。父亲经验丰富的绒猴Callithrix Jacchus暴露在与自己婴儿的气味直接隔离的嗅觉接触中，在20分钟内睾丸激素水平迅速下降，而父亲经验不足的雄性则不会。我们测试了依赖婴儿(自己的和新的)和独立的婴儿(自己的和新的)对暴露于婴儿气味是否有不同的类固醇反应。我们测定了8只雄性恒河猴在接触隔离婴儿气味20分钟后的血清雌二醇、雌酮、睾酮、双氢睾酮(DHT)及雌雄激素结合水平。睾丸激素水平显著受气味相关性的影响；暴露在自己的婴儿气味中的睾丸激素水平显著低于新的婴儿气味。雌激素水平显著升高，对自己的婴儿气味做出反应。睾酮水平的显着差异并不被视为相关婴儿的年龄因素，但雌激素水平的增加是显着的。这些结果表明，绒猴父亲对来自相关婴儿的启动提示有反应，这种反应可能会持续到婴儿依赖期之后。 我们还发现，增加的雌二醇显著地刺激男性对幼小男性的婴儿求救信号更加关注。没有当过父亲的男性对婴儿刺激的反应很小，而有经验的父亲对婴儿刺激表现出显著的反应。我们目前正在评估来自完整的前叶和后叶的垂体多巴胺、催产素、加压素和催乳素水平的变化，以及分别为有经验和幼稚的男性培养的每个垂体腺。初步结果显示，有经验的父亲和天真的男性在催乳素和催产素水平上存在显著差异，但没有后叶加压素的水平。有经验的父亲的催乳素和催产素显著高于没有经验的父亲。 这项研究项目依赖于WNPRC化验服务、动物服务和临床病理学。 出版物： 齐格勒·特，彼得森LJ，索萨·梅，巴纳德·AM常见绒猴(Callithrix Jacchus)父亲对婴儿气味的内分泌反应。荷尔蒙和行为。2010年12月9日[印刷前夕]PMID：21145893。PMC3040271。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the factors underlying quality paternal care in male marmosets. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Marmosets are one of the few mammalian species whose social organization/family structure bears resemblance to that of humans. These studies are designed to determine the hormonal pathway for priming paternal care behaviors in biparental males who show extensive parental care. Olfactory cues can exert priming effects on many mammalian species. Paternally experienced marmosets, Callithrix jacchus, exposed to direct isolated olfactory contact with their own infant's scent show rapid decreases in testosterone levels within 20 minutes, whereas paternally inexperienced males do not. We tested whether there is a differential steroid response to exposure of infant scent from dependent infants (own and novel) and independent infants (own and novel). We examined the serum levels of estradiol, estrone, testosterone, dihydrotestosterone (DHT), and combined estrogens and androgens in eight male marmosets 20 minutes after exposure to isolated infant scent. Testosterone levels were significantly influenced by the relatedness of the scent; testosterone levels were significantly lower with exposure to own infant scent than a novel infant scent. Estrogen levels elevated significantly in response to own infant scent. Significant differences in testosterone levels were not seen as a factor of age for the related infant but increased estrogens were significant. These results suggest that marmoset fathers are responsive to priming cues from related infants and that responsiveness may last beyond the period of infant dependence. We have also found that increased estradiol significantly stimulates males to be more attentive to infant distress signals in na¿ve males. Males who have not been fathers before show little responsiveness to infant stimuli while experienced fathers show significant response to infant stimuli. We are currently assessing the variation in pituitary levels of dopamine, oxytocin, vasopressin and prolactin from intact anterior and posterior pituitaries as well as each pituitary cultured separately for experienced and na¿ve males. Initial results are revealing significant differences between experienced fathers and na¿ve males in their levels of prolactin and oxytocin but not vasopressin. Experienced fathers have significantly higher prolactin and oxytocin than na¿ve fathers. This research project relies on WNPRC Assay Services, Animal Services, and Clinical Pathology. PUBLICATION: Ziegler TE, Peterson LJ, Sosa ME, Barnard AM. Differential endocrine responses to infant odors in common marmoset (Callithrix jacchus) fathers. Hormones & Behavior . Dec 9 2010 [Epub ahead of print] PMID: 21145893. PMC3040271.