NEUROENDOCRINE CONTROL OF PATERNAL CARE IN THE COMMON MARMOSET

狨猴父亲照顾的神经内分泌控制

• 批准号: 8358226
• 负责人: Toni Elaine ZIEGLER
• 金额: $ 5.48万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358226
• 关键词: Androgens; Animals; Anterior Pituitary Gland; Behavior; Biological Assay; Callithrix; Callithrix jacchus jacchus; Caring; Clinical Pathology; Cues; Dependence; Disease; Distress; Dopamine; Endocrine; Estradiol; Estrogens; Estrone; Exposure to; Fathers; Funding; Grant; Health; Hormonal; Hormones; Human; Infant; National Center for Research Resources; Neurosecretory Systems; Odors; Oxytocin; Parenting behavior; Pathway interactions; Pituitary Gland; Posterior Pituitary Gland; Primates; Principal Investigator; Printing; Prolactin; Research; Research Design; Research Infrastructure; Research Project Grants; Resources; Serum; Services; Signal Transduction; Source; Stanolone; Steroids; Stimulus; Testing; Testosterone; United States National Institutes of Health; Ursidae Family; Variant; Vasopressins; Wisconsin; age related; cost; experience; family structure; male; novel; psychosocial; response; social organization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To determine the factors underlying quality paternal care in male marmosets. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Marmosets are one of the few mammalian species whose social organization/family structure bears resemblance to that of humans. These studies are designed to determine the hormonal pathway for priming paternal care behaviors in biparental males who show extensive parental care. Olfactory cues can exert priming effects on many mammalian species. Paternally experienced marmosets, Callithrix jacchus, exposed to direct isolated olfactory contact with their own infant's scent show rapid decreases in testosterone levels within 20 minutes, whereas paternally inexperienced males do not. We tested whether there is a differential steroid response to exposure of infant scent from dependent infants (own and novel) and independent infants (own and novel). We examined the serum levels of estradiol, estrone, testosterone, dihydrotestosterone (DHT), and combined estrogens and androgens in eight male marmosets 20 minutes after exposure to isolated infant scent. Testosterone levels were significantly influenced by the relatedness of the scent; testosterone levels were significantly lower with exposure to own infant scent than a novel infant scent. Estrogen levels elevated significantly in response to own infant scent. Significant differences in testosterone levels were not seen as a factor of age for the related infant but increased estrogens were significant. These results suggest that marmoset fathers are responsive to priming cues from related infants and that responsiveness may last beyond the period of infant dependence. We have also found that increased estradiol significantly stimulates males to be more attentive to infant distress signals in na¿ve males. Males who have not been fathers before show little responsiveness to infant stimuli while experienced fathers show significant response to infant stimuli. We are currently assessing the variation in pituitary levels of dopamine, oxytocin, vasopressin and prolactin from intact anterior and posterior pituitaries as well as each pituitary cultured separately for experienced and na¿ve males. Initial results are revealing significant differences between experienced fathers and na¿ve males in their levels of prolactin and oxytocin but not vasopressin. Experienced fathers have significantly higher prolactin and oxytocin than na¿ve fathers. This research project relies on WNPRC Assay Services, Animal Services, and Clinical Pathology. PUBLICATION: Ziegler TE, Peterson LJ, Sosa ME, Barnard AM. Differential endocrine responses to infant odors in common marmoset (Callithrix jacchus) fathers. Hormones & Behavior . Dec 9 2010 [Epub ahead of print] PMID: 21145893. PMC3040271.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目的：确定雄性果酱中质量父亲护理的基本因素。 由于育儿或父母的缺席，有许多使人健康混淆的社会心理障碍。摩尔果是其社会组织/家庭结构与人类相似的少数哺乳动物物种之一。这些研究旨在确定表现出广泛的父母护理的二聚体男性启动父亲护理行为的马途径。嗅觉提示会对许多哺乳动物物种产生启动作用。亲子经验丰富的果果Callithrix jacchus在20分钟内与自己婴儿的疤痕迅速在睾丸激素水平上接触了直接孤立的嗅觉接触，而亲子经验不足的雄性则没有。我们测试了对依赖婴儿（自己和新颖）和独立婴儿（自己和新颖）的婴儿疤痕暴露的立体声反应是否有不同的反应。我们检查了雌二醇，睾丸激素，二氢睾丸激素（DHT）的血清水平，以及在暴露于孤立的婴儿稀缺性稀缺后20分钟的八个雄性果胶中八个雄性果胶中的雌激素和雄激素的组合。睾丸激素水平受到稀缺性相关性的显着影响。睾丸激素水平明显低于婴儿稀缺性，而睾丸激素水平比新颖的婴儿稀缺性较低。雌激素水平显着升高，以响应自己的婴儿稀缺性。睾丸激素水平的显着差异并未视为相关婴儿年龄的因素，但强度的增加很大。这些结果表明，马尔莫斯特父亲对相关婴儿的启动提示有反应，并且反应能力可能会超过婴儿依赖时期。 我们还发现，雌二醇增加会显着刺激雄性对雄性的婴儿遇险信号更加专注。在经验丰富的父亲表现出对婴儿刺激的重大反应时，对婴儿刺激的反应很小，但对婴儿刺激的反应很少。我们目前正在评估多巴胺，氧气，加压素和催乳素的垂体水平的变化，从完整的前和后垂体以及每种垂体培养的垂体和经验丰富的男性分别培养。最初的结果表明，经验丰富的父亲和纳雷斯之间的催乳素和氧气水平上没有差异，但没有加压素。经验丰富的父亲的催乳素和氧气明显高于Na¿ 该研究项目依赖于WNPRC测定服务，动物服务和临床病理学。 发布： Ziegler TE，Peterson LJ，Sosa ME，Barnard AM。内分泌对婴儿气味的差异反应（Callithrix Jacchus）父亲。激素与行为。 2010年12月9日[EPUB在印刷前] PMID：21145893。PMC3040271。