NEUROENDOCRINE CONTROL OF PATERNAL CARE IN THE COMMON MARMOSET

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：探讨影响雄性绒猴优质父爱的因素。 由于父母养育不当或父母不在，有一些心理社会障碍困扰着人类健康。 绒猴是为数不多的社会组织/家庭结构与人类相似的哺乳动物物种之一。 这些研究的目的是确定激素途径的启动父亲的照顾行为，在双亲男性谁表现出广泛的父母照顾。随着赠款的第一年结束，我们有所有具体的目标正在进行中。 在具体的目标1中，我们发现，增加雌二醇显着刺激男性更注意婴儿的遇险信号在天真的男性。 没有做过父亲的男性对婴儿刺激的反应很小，而有经验的父亲对婴儿刺激的反应很大。 在具体目标2和3中，我们测量了完整的垂体前叶和垂体后叶的垂体细胞中的多巴胺、催产素、血管加压素和催乳素，以及分别培养的有经验和未受过训练的男性的每个垂体。 初步结果显示，经验丰富的父亲和天真的男性之间的催乳素和催产素水平有显着差异，但没有加压素。 有经验的父亲比没有经验的父亲有更高的催乳素和催产素。 该研究项目现已进入第二年，依赖于WNPRC分析服务和动物服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the factors underlying quality paternal care in male marmosets. With poor parenting or parental absence, there are a number of psychosocial disorders that confound human health. Marmosets are one of the few mammalian species whose social organization/family structure bears resemblance to that of humans. These studies are designed to determine the hormonal pathway for priming paternal care behaviors in biparental males who show extensive parental care. With the first year of the grant ending, we have all specific aims ongoing. In specific aim 1 we have found that increased estradiol significantly stimulates males to be more attentive to infant distress signals in na¿ve males. Males who have not been fathers before show little responsiveness to infant stimuli while experienced fathers show significant response to infant stimuli. In specific aim 2&3 we are measuring dopamine, oxytocin, vasopressin and prolactin in pituitary cells of intact anterior and posterior pituitaries as well as each pituitary cultured separately for experienced and na¿ve males. Initial results are revealing significant differences between experienced fathers and na¿ve males in their levels of prolactin and oxytocin but not vasopressin. Experienced fathers have significantly higher prolactin and oxytocin than na¿ve fathers. This research project, now in its second year, relies on WNPRC Assay Services and Animal Services.