Membrane interactions and neurotoxicity of Amyloid Abeta peptides from Alzheimer's disease.

阿尔茨海默氏病淀粉样 Aβ 肽的膜相互作用和神经毒性。

• 批准号: DP0664601
• 负责人: Prof Frances Separovic
• 金额: $ 22.86万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664601
• 关键词: Membrane; interactions; neurotoxicity; Amyloid; Abeta

A consequence of the increase in human life span is that age-related neurodegenerative diseases such as Alzheimer's disease (AD) are more prevalent. Currently there are limited therapeutic treatments and no cure for AD. The key protein causing AD is Abeta and characterization of the toxic species of this peptide is critical towards identifying potential therapeutic targets. This proposal aims to study mutant peptides made synthetically and to identify a membrane-binding site. By establishing which lipid is critically involved in membrane binding of Abeta and mediating subsequent cell death, drugs may be developed to prevent the binding of Abeta to membranes resulting in neuronal survival and prevention of memory loss in AD patients.

人类寿命延长的一个后果是与年龄相关的神经退行性疾病（例如阿尔茨海默病（AD））更加普遍。目前，AD的治疗方法有限，无法治愈。导致AD的关键蛋白是Abeta，并且该肽的毒性种类的表征对于鉴定潜在的治疗靶标至关重要。该提案旨在研究合成的突变肽，并确定膜结合位点。通过确定哪种脂质关键性地参与Abeta的膜结合并介导随后的细胞死亡，可以开发药物来防止Abeta与膜的结合，从而导致AD患者的神经元存活和预防记忆丧失。