Membrane Protein Structure and Interaction Facility

膜蛋白结构和相互作用设施

• 批准号: LE0668017
• 负责人: Prof Frances Separovic
• 金额: $ 69.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE0668017
• 关键词: Membrane; Protein; Structure; Interaction; Facility

While it is estimated that a third of the human genome encodes for membrane proteins, the structures of only relatively few membrane proteins are currently known. It will be some time before membrane protein structure determination becomes routine, yet over 50% of the drugs on the market today rely on the activity of membrane proteins for their efficacy. This application seeks to establish a Membrane Protein Structure and Interaction Facility for the development and application of novel techniques and approaches to study the structure and interactions of membrane proteins. Research progress will be greatly enhanced by the establishment of this dedicated facility with cutting-edge technologies for the study of membrane proteins.

虽然据估计，三分之一的人类基因组编码膜蛋白，但目前已知的膜蛋白结构相对较少。膜蛋白结构的测定还需要一段时间才能成为常规，但目前市场上超过50%的药物依赖于膜蛋白的活性来发挥作用。本申请旨在建立膜蛋白结构和相互作用设施，用于开发和应用研究膜蛋白结构和相互作用的新技术和方法。通过建立这一拥有尖端技术的膜蛋白研究专用设施，将极大地促进研究进展。