Atomic details of antimicrobial peptides at work in live cells

该项目旨在开发方法来确定活细胞中生物学重要分子的详细结构，以更好地了解生物分子结构如何与疾病相关。生命分子在原子水平上的结构通常以模型系统中的晶体或溶液研究为特征。然而，许多生物学上重要分子的结构取决于它们的环境。使用新的仪器和标签方案，该项目计划使用核磁共振方法研究活细菌和人类细胞中的抗生素和抗菌肽。目标是解决这些分子如何穿过细胞膜以及生物分子结构如何与活性相关的问题，这可能会推动生物技术和治疗耐药感染的发展。

This project aims to develop methods to determine the detailed structure of biologically important molecules in live cells to better understand how biomolecular structure is related to disease. The structure at the atomic level of the molecules of life is usually characterised by crystal or solution studies in model systems. However, the structure of many biologically important molecules depends on their environment. Using new instrumentation and labelling schemes, the project plans to use nuclear magnetic resonance methods to study antibiotics and antimicrobial peptides in live bacteria and human cells. The goal is to resolve how these molecules cross cell membranes and how biomolecular structure is related to activity, which may advance development in biotechnology and therapeutic treatments against drug-resistant infections.