Rehabilitation of cancer cells
Rehabilitation of cancer cells
批准号:
23659206
负责人:
HINO Okio
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Normal rat’s and Eker (Tsc2+/-) rat’s ESCs were established. Oct4, Sox2, Nanog were expressed in these ERCs. We injected ESCs under the kidney capsule of nude mice. Tsc2-/-teratomas were capable to differentiate into various cell types derived from three germ layers. However, they showed abnormal epithelial structures, resemble to RCC tissues in Eker rats. We suggest that tissue specific abnormal cellular differentiation caused by Tsc2-deficiency was recaptured by teratoma formation
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Preventing of alveolar destruction and airspace enlargement in a mouse Model of pulmonary lymphangioleiomyomatosis (LAM)
预防肺淋巴管肌瘤病 (LAM) 小鼠模型中的肺泡破坏和空腔扩大
DOI:
--
发表时间:
2012
期刊:
Science Translational Medicine
影响因子:
17.1
作者:
[Goncharova E.A., Goncharov D.A., Fehrenbach M., Khavin I., Ducka B., Hino O., Colby T.V., Merrilees M.J., Haczku A., Albelada S.M. and Krymskaya V.]
通讯作者:
Albelada S.M. and Krymskaya V.
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
NRF2通过p62在肝细胞癌细胞中的持续激活。
DOI:
10.1083/jcb.201102031
发表时间:
2011-04-18
期刊:
The Journal of cell biology
影响因子:
--
作者:
[Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M]
通讯作者:
Komatsu M
DOI:
10.1038/ncomms2295
发表时间:
2012
期刊:
Nature communications
影响因子:
16.6
作者:
[]
通讯作者:
DNA binding protein A exression and methylation status in hepatocellular carcinoma and the adjacent tissue
肝细胞癌及癌旁组织中DNA结合蛋白A的表达及甲基化状态
DOI:
--
发表时间:
2012
期刊:
Int. J. Oncology
影响因子:
--
作者:
[Yasen M., Obulhasim G., Kajino K., Mogushi K., Mizushima H., Tanaka S., Tanaka H., Hino O. and Arii S]
通讯作者:
Hino O. and Arii S
DOI:
10.1371/journal.pone.0054503
发表时间:
2013
期刊:
PloS one
影响因子:
3.7
作者:
[Ohsawa M, Kobayashi T, Okura H, Igarashi T, Mizuguchi M, Hino O]
通讯作者:
Hino O
共 12 条
Rehabilitation of cancer cells
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批准号:25670196
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2013
-
负责人:HINO Okio
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依托单位:
Risk evaluation of environmental carcinogenesis
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批准号:22240093
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$27.87万
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财政年份:2010
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负责人:HINO Okio
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依托单位:
The study of multistep carcinogenesis using unique animal models
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批准号:17013076
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$31.04万
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财政年份:2005
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负责人:HINO Okio
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依托单位:
Molecular mechanism of hypercarcinogenic state -inflammation-induced hepatocarcinogenesis-
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批准号:16390121
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2004
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负责人:HINO Okio
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依托单位:
Multi-step carcinogenesis using genetically retired models
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批准号:12213139
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$34.62万
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财政年份:2000
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负责人:HINO Okio
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依托单位:
Multistage carcinogenesis in TSC gene mutant models
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批准号:08264108
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$68.48万
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财政年份:1999
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负责人:HINO Okio
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依托单位:
Pathogenesis of Human Tuberous Sclerosis
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批准号:09470068
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.16万
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财政年份:1997
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负责人:HINO Okio
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依托单位:
Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma
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批准号:06454719
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1994
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负责人:HINO Okio
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依托单位:
海外基金