Rehabilitation of cancer cells

癌细胞的康复

• 批准号: 23659206
• 负责人: HINO Okio
• 金额: $ 2.41万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659206/
• 关键词: 疾患モデル動物; リプログラミング; iPS化; Tsc変異体; がん幹細胞; 遺伝性がん

Normal rat’s and Eker (Tsc2+/-) rat’s ESCs were established. Oct4, Sox2, Nanog were expressed in these ERCs. We injected ESCs under the kidney capsule of nude mice. Tsc2-/-teratomas were capable to differentiate into various cell types derived from three germ layers. However, they showed abnormal epithelial structures, resemble to RCC tissues in Eker rats. We suggest that tissue specific abnormal cellular differentiation caused by Tsc2-deficiency was recaptured by teratoma formation

建立正常大鼠和Eker(TSC2+/-)大鼠胚胎干细胞。这些内皮细胞表达Oct4、Sox2、Nanog。我们将胚胎干细胞注射到裸鼠的肾被膜下。TSC2-/-畸胎瘤可分化为三种胚层来源的不同细胞类型。然而，它们显示出异常的上皮结构，类似于Eker大鼠的肾癌组织。我们认为TSC2缺乏引起的组织特异性细胞分化异常是通过畸胎瘤的形成重新获得的。

项目成果

Preventing of alveolar destruction and airspace enlargement in a mouse Model of pulmonary lymphangioleiomyomatosis (LAM)

预防肺淋巴管肌瘤病 (LAM) 小鼠模型中的肺泡破坏和空腔扩大

• 发表时间: 2012
• 期刊: Science Translational Medicine
• 影响因子: 17.1
• 作者: Goncharova E.A.;Goncharov D.A.;Fehrenbach M.;Khavin I.;Ducka B.;Hino O.;Colby T.V.;Merrilees M.J.;Haczku A.;Albelada S.M. and Krymskaya V.
• 通讯作者: Albelada S.M. and Krymskaya V.

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.

NRF2通过p62在肝细胞癌细胞中的持续激活。

• DOI: 10.1083/jcb.201102031
• 发表时间: 2011-04-18
• 期刊: The Journal of cell biology
• 作者: Inami Y;Waguri S;Sakamoto A;Kouno T;Nakada K;Hino O;Watanabe S;Ando J;Iwadate M;Yamamoto M;Lee MS;Tanaka K;Komatsu M
• 通讯作者: Komatsu M

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.

• DOI: 10.1038/ncomms2295
• 发表时间: 2012
• 期刊: Nature communications
• 影响因子: 16.6

DNA binding protein A exression and methylation status in hepatocellular carcinoma and the adjacent tissue

肝细胞癌及癌旁组织中DNA结合蛋白A的表达及甲基化状态

• 发表时间: 2012
• 期刊: Int. J. Oncology
• 作者: Yasen M.;Obulhasim G.;Kajino K.;Mogushi K.;Mizushima H.;Tanaka S.;Tanaka H.;Hino O. and Arii S
• 通讯作者: Hino O. and Arii S

TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity.

• DOI: 10.1371/journal.pone.0054503
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ohsawa M;Kobayashi T;Okura H;Igarashi T;Mizuguchi M;Hino O
• 通讯作者: Hino O