Rehabilitation of cancer cells

癌细胞的康复

• 批准号: 25670196
• 负责人: HINO Okio
• 金额: $ 2.33万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670196/
• 关键词: 癌; 病理学; 再生医療; 遺伝子; ips化; Tsc遺伝子; 遺伝学; 初期化

项目成果

Rheb-syntenin interaction regulates dendritic spine formation in rodent models of tuberous sclerosis.

Rheb-syntenin 相互作用调节结节性硬化症啮齿动物模型中树突棘的形成。

• 发表时间: 2014
• 期刊: PNAS
• 作者: 285.Sugiura H.;Yasuda S.;Katsurabayashi S.;Oguri K.;Tanaka H.;Takasaki K.;Iwasaki K.;Kobayashi T.;Hino O. and Yamagata K.
• 通讯作者: Hino O. and Yamagata K.

TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity.

• DOI: 10.1371/journal.pone.0054503
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ohsawa M;Kobayashi T;Okura H;Igarashi T;Mizuguchi M;Hino O
• 通讯作者: Hino O

Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.

• DOI: 10.1038/srep05927
• 发表时间: 2014-08-04
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Shiono M;Kobayashi T;Takahashi R;Ueda M;Ishioka C;Hino O
• 通讯作者: Hino O

Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex

• DOI: 10.1038/ncomms7842
• 发表时间: 2015-04
• 期刊: Nature Communications
• 影响因子: 16.6
• 作者: H. Sugiura;Shin Yasuda;S. Katsurabayashi;Hiroyuki Kawano;Kentaro Endo;Kotaro Takasaki;K. Iwasaki;M. Ichikawa;Toshiyuki Kobayashi;O. Hino;K. Yamagata

Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.

• DOI: 10.1038/srep05155
• 发表时间: 2014-06-03
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Yasuda S;Sugiura H;Katsurabayashi S;Shimada T;Tanaka H;Takasaki K;Iwasaki K;Kobayashi T;Hino O;Yamagata K
• 通讯作者: Yamagata K