Risk evaluation of environmental carcinogenesis

我们报道了N-ERC/mesothelin可能是间皮瘤有用的血液肿瘤标志物。为了研究这种肿瘤标志物是否有助于在大规模检查中进行早期诊断，我们在日本对有石棉暴露风险的建筑工人进行了大规模的试点研究筛选。总之，血液肿瘤标志物在肿块检查中有助于早期诊断，并可能延长患者的生存期。我们已经证明，即使在腹腔注射多壁碳纳米管、人造矿物纤维或温石棉后10周，大鼠的血浆N-ERC水平也持续高于其他非致癌物质。

We reported N-ERC/mesothelin might be a useful blood tumor marker for mesothelioma. In order to investigate whether this tumor marker is useful for an early diagnosis in a mass examination, we started a large-scale pilot research screening in Japan for construction workers with the risk of asbestos exposure. In conclusion, it is indicated that the blood tumor marker is useful for an early diagnosis in a mass examination and may lead to the prolongation of their survival. We havedemonstrated that plasma N-ERC levels of rats administered multi-wall carbon nanotube, man-made mineral fibers or chrysotile were continuously higher even at 10 weeks after intraperitoneal (i.p.) injection than the other non-carcinogenic materials.