Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma
Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma
批准号:
06454719
负责人:
HINO Okio
金额:
$4.1万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1994
资助国家:
日本
项目状态:
已结题
起止时间:
1994 至 1995
中文摘要
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英文摘要
The Eker rat model of hereditary renal carcinoma, originally reported by R.Eker in 1954, is an example of Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Finally, we identified a germline retrotransposon insertion in the rat homologue of the human tuberous sclerosis (TSC2) gene, 40 years after the discovery of the Eker rat in Oslo.
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Kubo,Y.: "Allelic Loss at the Predisposing Gene Locus in Spontaneous and Chemically Induced Renal Cell Carcinomas in the Eker Rat^1" Cancer Res.54. 2633-2635 (1994)
Kubo,Y.:“Eker 大鼠自发性和化学诱导的肾细胞癌^1 中易感基因位点的等位基因丢失”Cancer Res.54。
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Hino,O.: "Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis(TSC2)" Molecular Carcinogenesis. 14. 23-27 (1995)
Hino,O.:“结节性硬化症 Eker 大鼠模型 (TSC2) 肾癌发生的分子遗传学基础”分子癌变。
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Kobayashi,T.: "The structure of the rat tuberous sclerosis(Tsc2) gene." Rat Genome.1-2. 6-10 (1995)
Kobayashi,T.:“大鼠结节性硬化症(Tsc2)基因的结构。”
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Kobayashi, T.and Hino, O.: "Close proximity of the rat Tsc2 and Pkdl genes.Rat Genome" (in press.).
Kobayashi, T. 和 Hino, O.:“大鼠 Tsc2 和 Pkdl 基因的紧密接近。大鼠基因组”(正在出版)。
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Kikuchi,Y.: "Cloning of the rat homologue of the von Hippel-Lindau (VHL) tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas." Jap.J.Cancer Res.86. 905-909 (1995)
Kikuchi,Y.:“von Hippel-Lindau (VHL) 肿瘤抑制基因的大鼠同源物的克隆及其在大鼠肾细胞癌中的非体细胞突变。”
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共 59 条
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