The study of multistep carcinogenesis using unique animal models
The study of multistep carcinogenesis using unique animal models
批准号:
17013076
负责人:
HINO Okio
金额:
$31.04万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
We investigated the unique animal models for the study of problems in carcinogenesis; eg., multistep carcinogenesis, cancer prevention and the development of the therapeutic treatments which can be translated into human patients. We discovered the ERC gene in Eker rat model (Tsc2 gene mutant). We developed a novel ELISA system for human asbestos-related mesothelioma. We have started a large-scale prospective study on building construction workers using our ELISA system.
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DOI:
10.1128/jvi.01063-07
发表时间:
2007-10-01
期刊:
JOURNAL OF VIROLOGY
影响因子:
5.4
作者:
[Minami, Kahori, Tambe, Yukihiro, Inoue, Hirokazu]
通讯作者:
Inoue, Hirokazu
Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnipl-like (FnipL/Fnip2) protein.
卵泡素(Birt-Hogg-Dube 基因产物)与新型 Fnipl 样 (FnipL/Fnip2) 蛋白的相互作用。
DOI:
--
发表时间:
2008
期刊:
Oncogene 27
影响因子:
--
作者:
[Takagi Y., Kobayashi, T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., Hino O.]
通讯作者:
Hino O.
Establishment of the ELISA system to detect the amino terminal secretory form of rat Erc/ Mesothelin.
大鼠Erc/间皮素氨基末端分泌型ELISA检测系统的建立。
DOI:
--
发表时间:
2007
期刊:
Cancer Sci. 98
影响因子:
--
作者:
[Nakaishi M., Kajino K., Ikesue M., Hagiwara Y., Kuwahara M., Mitani H., Horikoshi Y., Segawa T., Kon S., Maeda M., Baiyin T., Abe M., Yokoyama M., Hino O.]
通讯作者:
Hino O.
Establishment of the ELISA system to detect the amino terminal secretory form of rat Erc/Mesothelin.
大鼠Erc/间皮素氨基末端分泌型ELISA检测系统的建立。
DOI:
--
发表时间:
2007
期刊:
Cancer Science 98
影响因子:
--
作者:
[Nakanishi, M., et. al.]
通讯作者:
et. al.
Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.
通过引入野生型 Bhd 基因,转基因挽救日本大鼠模型中的胚胎致死和肾癌。
DOI:
--
发表时间:
2005
期刊:
Oncogene (In press)
影响因子:
--
作者:
[Togashi Y, Hino O., et al.]
通讯作者:
et al.
共 49 条
Rehabilitation of cancer cells
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批准号:25670196
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2013
-
负责人:HINO Okio
-
依托单位:
Rehabilitation of cancer cells
-
批准号:23659206
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:HINO Okio
-
依托单位:
Risk evaluation of environmental carcinogenesis
-
批准号:22240093
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$27.87万
-
财政年份:2010
-
负责人:HINO Okio
-
依托单位:
Molecular mechanism of hypercarcinogenic state -inflammation-induced hepatocarcinogenesis-
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批准号:16390121
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2004
-
负责人:HINO Okio
-
依托单位:
Multi-step carcinogenesis using genetically retired models
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批准号:12213139
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$34.62万
-
财政年份:2000
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负责人:HINO Okio
-
依托单位:
Multistage carcinogenesis in TSC gene mutant models
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批准号:08264108
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$68.48万
-
财政年份:1999
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负责人:HINO Okio
-
依托单位:
Pathogenesis of Human Tuberous Sclerosis
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批准号:09470068
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.16万
-
财政年份:1997
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负责人:HINO Okio
-
依托单位:
Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma
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批准号:06454719
-
项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1994
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负责人:HINO Okio
-
依托单位: