Effects of neuromodulator on sub-network structure during perceptual computation

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The objective of the present work was to elucidate how neuromodulator affected formation and/or stability of functional assembly of neural population in the sensory cortex. In particular, we investigated VNS-induced modulation of neural activities in the auditory cortex because VNS activates serotonergic and noradrenergic systems that globally affect the cerebral cortex. Consequently, we demonstrated that VNS modulates the local synchrony of spontaneous cortical activities in a state-dependent manner and that VNS alters the selectivity and time resolution of auditory evoked responses.