High-dense CMOS electrode array to investigate neuronal network in culture

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The network configuration and activities in dissociated cultures of neurons were investigated using high-density CMOS microelectrode array with 11,011 recording sites within 1.8 x 1.8 mm2. Our data demonstrated that the conduction velocity of action potential along an axon varies within an identical cell; the velocity was high at thick parts of axon, while low at thin parts. We also demonstrated that low-firing-rate neurons migrate actively. Furthermore, spatio-temporal patterns evoked by single axon stimulation were proved useful to quantify the functional connectivity and plasticity within the network.