Analysis of adiponectin and drugs improving insulin resistance in colorectal carcinogenesis

脂联素和改善胰岛素抵抗的药物在结直肠癌发生中的分析

• 批准号: 21790679
• 负责人: TAKAHASHI Hirokazu
• 金额: $ 2.75万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790679/
• 关键词: 大腸癌; アディポネクチン; ACF; PPARγ; metformin; 大腸がん

Obesity and its associated visceral fat accumulation have been reported to be linked to an elevated risk of cardiovascular disease, diabetes mellitus, and mortality, and these complications are rapidly becoming significant problems. Visceral adipose tissue is not only fat storage tissue, but also a metabolically active organ secreting many adipocytokines, such as adiponectin. Obesity is reportedly an important risk factor for CRC. Adiponectin and drugs improving insulin resistance for inhibiting colorectal carcinogenesis in mouse model and humans provides preliminary evidence, suggesting its promise for the chemoprevention of colorectal cancer. Further studies should be conducted to clarify the role that visceral fat accumulation and reduced plasma adiponectin play in obesity-related CRC prevention.

据报道，肥胖及其相关的内脏脂肪堆积与心血管疾病、糖尿病和死亡率的风险增加有关，这些并发症正迅速成为重大问题。内脏脂肪组织不仅是储存脂肪的组织，而且是分泌脂联素等多种脂肪细胞因子的代谢活跃器官。据报道，肥胖是结直肠癌的一个重要风险因素。脂联素和改善胰岛素抵抗的药物在小鼠模型和人类中抑制结直肠癌的发生提供了初步证据，表明其有望用于结直肠癌的化学预防。应进一步研究以阐明内脏脂肪堆积和血浆脂联素降低在肥胖相关的CRC预防中所起的作用。

项目成果

Leptin regulates colorectal tumor growth through Stat3 signaling

瘦素通过 Stat3 信号传导调节结直肠肿瘤生长

• 发表时间: 2010
• 作者: Endo H;Uchiyama T;Sakai E;Sugiyama M;Hosono K;Takahashi H;Maeda S;Nakajima A
• 通讯作者: Nakajima A

肥満と大腸がん

肥胖与结直肠癌

• 发表时间: 2010
• 作者: 中島淳;高橋宏和
• 通讯作者: 高橋宏和

大腸腫瘍におけるレプチンシグナル経路の解析

结直肠肿瘤瘦素信号通路分析

• 发表时间: 2010
• 作者: 内山崇;高橋宏和;中島淳
• 通讯作者: 中島淳

JNK plays a crucial role in promotion of the early stage of colon carcinogenesis under the high-fat diet condition

高脂饮食条件下JNK对早期结肠癌的发生起着至关重要的作用

• 发表时间: 2009
• 作者: Endo H;Hosono K;Yoneda;K;Takahashi H;Nakajima A
• 通讯作者: Nakajima A

抗糖尿病薬メトホルミンを用いた生活習慣病における大腸癌の予防戦略

使用抗糖尿病药物二甲双胍预防生活方式相关疾病中结直肠癌的策略

• 发表时间: 2010
• 作者: 細野邦広;遠藤宏樹;高橋宏和;稲森正彦;中島淳
• 通讯作者: 中島淳