Relationships of the immune-cells dynamic state in circulatory blood and regulations of cardiovascular, autonomic nerve activity and hormonal secretion during exercise

运动时循环血中免疫细胞动态与心血管、自主神经活动、激素分泌调节的关系

• 批准号: 24650450
• 负责人: ICHINOSE Masashi
• 金额: $ 2.41万
• 依托单位: Meiji University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650450/
• 关键词: スポーツ免疫学; 循環調節; 自律神経調節; ＮＫ細胞; 末梢反射; NK細胞

In this study, we found that when the muscle metaboreflex activation by forearm muscle ischemia after the handgrip exercise caused increase in sympathetic nerve activity and secretion of catecholamine without large rise in circulatory blood flow, the circulating count of NK cells as well as NK cell cytotoxicity increased. In addition, when passive bicycle exercise induced increase in circulatory blood flow and the fall of catecholamine concentration, we found that the circulating count of helper T cells, killer T cells and B cells increased. These findings advance elucidation of regulatory mechanisms of immune-cells dynamic state in circulatory blood during exercise, and will be a significant academic base in considering the efficacy of the exercise training in promotion of health.

本研究发现，握力运动后前臂肌肉缺血引起的肌肉代谢性反射激活引起交感神经活性和儿茶酚胺的分泌量增加，而循环血流量没有明显增加时，NK细胞的循环计数以及NK细胞的细胞毒作用也随之增加。此外，当被动自行车运动导致循环血流量增加和儿茶酚胺浓度下降时，我们发现辅助T细胞、杀伤T细胞和B细胞的循环计数增加。这些发现有助于阐明运动过程中循环血液中免疫细胞动态的调节机制，并将为考虑运动训练促进健康的效果提供重要的理论依据。

项目成果

Increase in Exercising Leg Blood Flow Attenuates Systemic Cardiovascular Responses During Dynamic Planter Flexion Exercise

动态跖屈运动期间，运动腿部血流量的增加会减弱全身心血管反应

• 发表时间: 2013
• 作者: Ichinose M;Ichinose T;Nishiyasu T
• 通讯作者: Nishiyasu T

Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans

• DOI: 10.1007/s00421-012-2413-x
• 发表时间: 2012-05
• 期刊: European Journal of Applied Physiology
• 影响因子: 3
• 作者: Naoto Fujii;M. Ichinose;Y. Honda;B. Tsuji;Kazuhito Watanabe;N. Kondo;T. Nishiyasu

Muscle metaboreflex modulates dynamic cardiovascular and cerebrovascular responses to acute hypotension in humans

肌肉代谢反射调节人类急性低血压的动态心血管和脑血管反应

• 发表时间: 2012
• 作者: Ichinose M;Watanabe K;Tsuji B and Nishiyasu T
• 通讯作者: Tsuji B and Nishiyasu T

Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans.

• DOI: 10.3389/fphys.2012.00314
• 发表时间: 2012
• 期刊: Frontiers in physiology
• 影响因子: 4
• 作者: Ichinose M;Nishiyasu T
• 通讯作者: Nishiyasu T

Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans

肌肉代谢反射激活可加速人类急性低血压后动脉血压的恢复

• DOI: 10.1152/ajpheart.00833.2012
• 发表时间: 2013
• 期刊: American Journal of Physiology-Heart and Circulatory Physiology
• 影响因子: 4.8
• 作者: Masashi Ichinose;Kazuhito Watanabe、 Naoto Fujii;Narihiko Kondo and Takeshi Nishiyasu
• 通讯作者: Narihiko Kondo and Takeshi Nishiyasu