A challenge to apply nanodiamond into clinical medicine
A challenge to apply nanodiamond into clinical medicine
批准号:
24651135
负责人:
CHANO Tokuhiro
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
In vivo application of nanodaimond (ND) by polyglycerol hydrophilic covering was succeeded, and the diametrical selection caused a further success in passive targeting.RGD-peptide addition to ND (ND-RGD) could allow actiive targeting to cancer cells, and further, ester linkage between anticancer agent (CDDP) and ND-RGD could specifically enhance the cell death of U-87MG cells, which bare integrin aVb3. Such strategy as CDDP-ND-RGD can succeed anti-cancer active targeting therapy to eliminate non-specific CDDP toxicities, and to improve the cancer-specificity of the drug.
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Study of Global Transcriptional Changesof N-G1cNAc2 Proteins-Producing T24 Bladder Carcinoma Cells under Glucose Deprivation
葡萄糖剥夺下 T24 膀胱癌细胞 N-G1cNAc2 蛋白整体转录变化的研究
DOI:
--
发表时间:
2014
期刊:
PLoS One
影响因子:
3.7
作者:
[Isono T, Chano T, Okabe H, Suzaki M.]
通讯作者:
Suzaki M.
診療における新規マーカーの探索と適用
新标志物的寻找及临床应用
DOI:
--
发表时间:
2012
期刊:
臨床病理
影响因子:
--
作者:
[小林水緒, 角田優子, 原田憲一, 池田博子, 中沼安二, 茶野徳宏]
通讯作者:
茶野徳宏
Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway
drs肿瘤抑制因子通过mTOR依赖性途径抑制病毒复制
DOI:
10.1016/j.canlet.2011.09.015
发表时间:
2012
期刊:
Cancer Letters
影响因子:
9.7
作者:
[Tambe, Y., et al]
通讯作者:
et al
DOI:
10.1002/hed.21797
发表时间:
2012-05
期刊:
Head & Neck
影响因子:
--
作者:
[Hitosuke Tameno;T. Chano;K. Ikebuchi;Yasuko Ochi;A. Arai;M. Kishimoto;Taketoshi Shimada;Y. Hisa;H. Okabe]
通讯作者:
Hitosuke Tameno;T. Chano;K. Ikebuchi;Yasuko Ochi;A. Arai;M. Kishimoto;Taketoshi Shimada;Y. Hisa;H. Okabe
DOI:
10.1371/journal.pone.0032052
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Hama Y, Chano T, Inui T, Matsumoto K, Okabe H]
通讯作者:
Okabe H
共 8 条
海外基金