A role for Annexin A5 in the pregnancy

膜联蛋白A5（Annexin A5，Anxa5）是钙依赖性磷脂结合蛋白，是膜联蛋白家族蛋白质的一员。虽然已经假设Anxa5将参与胎盘中的抗凝作用，但没有直接证据。我们已经证明了Anxa5在妊娠期间的抗凝作用中具有至关重要的作用，通过使用Anxa5敲除小鼠。我们证实了血小板聚集发生在胎盘Anxa5KO。我们已经报道了这一点（科学，Rep. 2。827）。

Annexin A5 (Anxa5) is a calcium dependent phospholipid binding protein and a member of annexin family proteins. While it has been assumed that Anxa5 would be involved in the anticoagulant action in the placenta, there has no direct evidence. We have demonstrated that Anxa5 has a crucial role in the anticoagulation during pregnancy by using Anxa5 knockout mice. We confirmed that aggregation of platelets occurred in the placenta of Anxa5KO. We have reported this already (Sci, Rep. 2. 827).