A novel physiological function of mast cells on tissue remodeling

取得的显著成果概括如下。1)断奶后GnRH受体在乳腺的表达增强。2)卵巢肥大细胞的数量在一个发情周期内有两个高峰。这些峰值与GnRH mRNA在卵巢中的表达变化相一致。3)建立组织重塑模型，观察切除后大鼠前列腺组织学及肥大细胞数量的变化。前列腺切除后，肥大细胞、促性腺激素释放激素和膜联蛋白A5均增加。4)我们在促性腺激素中发现了两个新的信号分子，它们的表达被GnRH上调。本研究证实了肥大细胞在组织重塑中存在一种新的生理功能。

Remarkable results are summarized as following. 1) The expressionof GnRH receptor in the mammary gland is augmented after weaning. 2) The number of ovarian mast cells varies during an estrous cycle with two peaks. Those peaks matched with the variation of ovarian expression of GnRH mRNA. 3) As a tissue remodeling model, the changes in histology and mast cell number of prostate were examined after orchidectomy. Mast cell, GnRH and annexin A5 all were increased in the prostate gland after orchidectomy. 4) We found two new signaling agents in the gonadotropes those expression was increased by GnRH. By this research the existence of a novel physiological function at tissue remodeling of mast cell was demonstrated.