A novel physiological function of mast cells on tissue remodeling

肥大细胞在组织重塑中的新生理功能

• 批准号: 23380175
• 负责人: KAWAMINAMI Mitsumori
• 金额: $ 11.4万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380175/
• 关键词: マスト細胞; 組織リモデリング; 卵巣; 前立腺; 乳腺; アネキシンＡ５; GnRH; 下垂体; アネキシンA5

Remarkable results are summarized as following. 1) The expressionof GnRH receptor in the mammary gland is augmented after weaning. 2) The number of ovarian mast cells varies during an estrous cycle with two peaks. Those peaks matched with the variation of ovarian expression of GnRH mRNA. 3) As a tissue remodeling model, the changes in histology and mast cell number of prostate were examined after orchidectomy. Mast cell, GnRH and annexin A5 all were increased in the prostate gland after orchidectomy. 4) We found two new signaling agents in the gonadotropes those expression was increased by GnRH. By this research the existence of a novel physiological function at tissue remodeling of mast cell was demonstrated.

取得的显著成果概括如下。1)断奶后GnRH受体在乳腺的表达增强。2)卵巢肥大细胞的数量在一个发情周期内有两个高峰。这些峰值与GnRH mRNA在卵巢中的表达变化相一致。3)建立组织重塑模型，观察切除后大鼠前列腺组织学及肥大细胞数量的变化。前列腺切除后，肥大细胞、促性腺激素释放激素和膜联蛋白A5均增加。4)我们在促性腺激素中发现了两个新的信号分子，它们的表达被GnRH上调。本研究证实了肥大细胞在组织重塑中存在一种新的生理功能。

项目成果

Interferon (IFN) alpha stimulates the accumulation of Myxovirus (influenza virus) resistance 1 (Mx1) pseudo-gene transcripts including an intron-containing transcript in mouse pituitary gonadotropes: possible relation to intra-pituitary action of IFN-alp

干扰素 (IFN) α 刺激粘病毒（流感病毒）抗性 1 (Mx1) 假基因转录物的积累，包括小鼠垂体促性腺激素中含有内含子的转录物：可能与 IFN-alp 的垂体内作用有关

• 发表时间: 2013
• 作者: Ryota Terashima;Titalee Laoharatchatathanin;Tomohiro Yonezawa;Shiro Kurusu;Takako Kato;Yukio Kato;Kawaminami M
• 通讯作者: Kawaminami M

Maternal annexin A5 is required for preventing placental thrombosis and fetal loss

母体膜联蛋白 A5 是预防胎盘血栓形成和胎儿流产所必需的

• 发表时间: 2011
• 作者: Ueki H;Nishimura Y;Rieanrakwong D;Yonezawa T;Kurusu S;Hasegawa Y;Brachvogel B;Poschl E;Kawaminami M
• 通讯作者: Kawaminami M

Annexin A5 of maternal blood is prerequisite for preventing fetal loss during intact pregnancy

母血中的膜联蛋白 A5 是完整妊娠期间防止胎儿流产的先决条件

• 发表时间: 2012
• 作者: Kawaminami M;Ueki H;Nidhimuts Y;Rieanrakwong D;Yonezawa T;Kurusu S
• 通讯作者: Kurusu S

LH surge induces metastin expression in preovulatory follicles of rats

LH 激增诱导大鼠排卵前卵泡转移蛋白表达

• 作者: 加納 聖;久木友花;藤井 渉;内藤邦彦;日下部健;木曾康郎;村田幸久;Takahisa Murata;Laoharatchatathanin T
• 通讯作者: Laoharatchatathanin T

Annexin A5 is required for the development of the mammary gland

乳腺发育需要膜联蛋白 A5

• 发表时间: 2011
• 作者: Rieanrakwong D;Ueki H;Ozaki Y;Yonezawa T;Kurusu S;Hasegawa Y;Brachvogel B;Poschl E;Kawaminami M
• 通讯作者: Kawaminami M