Identification of factors enabling Group A Streptococcus reside without virulence

鉴定使 A 组链球菌无毒力驻留的因素

• 批准号: 24659197
• 负责人: HAMADA Shigeyuki
• 金额: $ 2.5万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659197/
• 关键词: A群レンサ球菌; 共生; 常在性; 破綻

Purpose of this project is to identify factors enabling Group A Streptococcus (GAS) reside without virulence in healthy person. As results, about 80 percent of healthy adult carry this bacteria without any disease. And improvement of culture methods for GAS isolation enabled the 32 GAS isolates from 13 persons. In addition, from the transcriptome analysis using microarray, we could identify 3 genes related to GAS residence inside human cells. From phylogenetic analysis, these genes can be shared with wide range of commensal bacteria and be transferred via bacteriophage. This indicates the genes may shed light on the new mechanisms to how commensal bacteria reside with human.

本项目的目的是确定使A组链球菌(GAS)在健康人体内无毒力生存的因素。结果，大约80%的健康成年人携带这种细菌，而没有任何疾病。而气体分离培养方法的改进，使13人共分离出32株气体。此外，从基因芯片的转录组分析中，我们还发现了3个与人体细胞内气体滞留相关的基因。从系统发育分析来看，这些基因可以与广泛的共生细菌共享，并通过噬菌体转移。这表明，这些基因可能有助于揭示细菌如何与人类共生的新机制。