Identification of factors enabling Group A Streptococcus reside without virulence
Identification of factors enabling Group A Streptococcus reside without virulence
批准号:
24659197
负责人:
HAMADA Shigeyuki
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
Purpose of this project is to identify factors enabling Group A Streptococcus (GAS) reside without virulence in healthy person. As results, about 80 percent of healthy adult carry this bacteria without any disease. And improvement of culture methods for GAS isolation enabled the 32 GAS isolates from 13 persons. In addition, from the transcriptome analysis using microarray, we could identify 3 genes related to GAS residence inside human cells. From phylogenetic analysis, these genes can be shared with wide range of commensal bacteria and be transferred via bacteriophage. This indicates the genes may shed light on the new mechanisms to how commensal bacteria reside with human.
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会议论文
Analysis of immune evasion system of Streptococcus pneumoniae
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批准号:23390103
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.65万
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财政年份:2011
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负责人:HAMADA Shigeyuki
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依托单位:
Tiling array analysis of transcriptional regulators in genus Streptococcus
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批准号:19390468
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.56万
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财政年份:2007
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负责人:HAMADA Shigeyuki
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依托单位:
Molecular analysis of the developmental mechanism of periodontal and oral diseases by the genome analysis of oral biofilm.
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批准号:17390485
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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财政年份:2005
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负责人:HAMADA Shigeyuki
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依托单位:
Molecular analysis of streptococcal infections diseases by the functional genomics.
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批准号:14207074
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.12万
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财政年份:2002
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负责人:HAMADA Shigeyuki
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依托单位:
Preventive strategy of marginal periodontitis by antimicrobial and adhesion-inhibitory basic peptides and protamines.
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批准号:11557132
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.38万
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财政年份:1999
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负责人:HAMADA Shigeyuki
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依托单位:
Molecular analyses on Streptococcus pyogenes adherence to and invasion of pharyngeal epithelial cells
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批准号:11307039
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$9.56万
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财政年份:1999
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负责人:HAMADA Shigeyuki
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依托单位:
Development studies on specific inhibitors of adherence of periodontal pathogen based on the etiology
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批准号:09557139
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.3万
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财政年份:1997
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负责人:HAMADA Shigeyuki
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依托单位:
Mechanisms of adherence of P.gingivalis to matrix proteins via fimbrial cryptie receptor
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批准号:08457480
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.67万
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财政年份:1996
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负责人:HAMADA Shigeyuki
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依托单位:
Development of mutacin MT6223 from Streptococcus sobrinus as an anti-caries agent
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批准号:06557099
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$5.95万
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财政年份:1994
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负责人:HAMADA Shigeyuki
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依托单位:
Bacterial endotoxic substances from periodontopathic bacteria and their effects on host cells
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批准号:05454192
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1993
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负责人:HAMADA Shigeyuki
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依托单位:
Studies on the pathogenesis of periodontal disease from the viewpoint of local immunity
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批准号:01480430
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.29万
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财政年份:1989
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负责人:HAMADA Shigeyuki
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依托单位:
Immunobiological Studies on the Pathogenic Mechanisms of Periodontal Disease
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批准号:01044085
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$7.23万
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财政年份:1989
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负责人:HAMADA Shigeyuki
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依托单位:
DEVELOPMENT OF LATEX AGGLUTINATION TEST FOR SPECIFIC DETECTION OF BACTEROIDES GINGIVALIS
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批准号:63870072
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$3.58万
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财政年份:1988
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负责人:HAMADA Shigeyuki
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依托单位:
Gene Cloning of Virulence Factors of Streptococcus mutans
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批准号:61480395
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$1.92万
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财政年份:1986
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负责人:HAMADA Shigeyuki
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依托单位:
国内基金
海外基金
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