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Analysis of immune evasion system of Streptococcus pneumoniae

Analysis of immune evasion system of Streptococcus pneumoniae
肺炎链球菌免疫逃避系统分析
批准号:
23390103
负责人:
HAMADA Shigeyuki
金额:
$12.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
Streptococcus pneumoniae is a common causative agent of pneumonia with high morbidity and mortality rates. In this study, we analyzed how Streptococcus pneumoniae evades host innate immunity. We revealed that pneumococcal a-enolase induce neutrophil extracellular trap formation and NETosis. Utilizing several biochemical assays and a recombinant procedure, a pneumococcal cell wall anchoring protein, PfbA, was found to function as an anti-phagocytic factor. In addition, we elucidated that S. pneumoniae invades human erythrocytes and escapes from neutrophil- and antibiotics-mediated killing.
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DOI: 10.1371/journal.pone.0088136
发表时间: 2014
期刊: PloS one
影响因子: 3.7
作者: [Okahashi N, Sumitomo T, Nakata M, Sakurai A, Kuwata H, Kawabata S]
通讯作者: Kawabata S
感染・炎症・免疫, タイでコレラに挑む
感染、炎症和免疫,应对泰国霍乱
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [岡田和久, 浜田茂幸]
通讯作者: 浜田茂幸
Streptococcus suis 全血清型の莢膜関連遺伝子群の解析
猪链球菌所有血清型荚膜相关基因分析
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [大倉正稔]
通讯作者: 大倉正稔
Streptcoccus pyogenes inhibits to form complement membrane attack complex
化脓性链球菌抑制补体膜攻击复合物的形成
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [寺尾豊, 川端重忠]
通讯作者: 川端重忠
63
    Identification of factors enabling Group A Streptococcus reside without virulence
    • 批准号:
      24659197
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      HAMADA Shigeyuki
    • 依托单位:
    Tiling array analysis of transcriptional regulators in genus Streptococcus
    • 批准号:
      19390468
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.56万
    • 财政年份:
      2007
    • 负责人:
      HAMADA Shigeyuki
    • 依托单位:
    Molecular analysis of the developmental mechanism of periodontal and oral diseases by the genome analysis of oral biofilm.
    • 批准号:
      17390485
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.79万
    • 财政年份:
      2005
    • 负责人:
      HAMADA Shigeyuki
    • 依托单位:
    Molecular analysis of streptococcal infections diseases by the functional genomics.
    • 批准号:
      14207074
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $32.12万
    • 财政年份:
      2002
    • 负责人:
      HAMADA Shigeyuki
    • 依托单位:
    海外基金