Analysis of immune evasion system of Streptococcus pneumoniae
Analysis of immune evasion system of Streptococcus pneumoniae
批准号:
23390103
负责人:
HAMADA Shigeyuki
金额:
$12.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
Streptococcus pneumoniae is a common causative agent of pneumonia with high morbidity and mortality rates. In this study, we analyzed how Streptococcus pneumoniae evades host innate immunity. We revealed that pneumococcal a-enolase induce neutrophil extracellular trap formation and NETosis. Utilizing several biochemical assays and a recombinant procedure, a pneumococcal cell wall anchoring protein, PfbA, was found to function as an anti-phagocytic factor. In addition, we elucidated that S. pneumoniae invades human erythrocytes and escapes from neutrophil- and antibiotics-mediated killing.
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DOI:
10.1371/journal.pone.0088136
发表时间:
2014
期刊:
PloS one
影响因子:
3.7
作者:
[Okahashi N, Sumitomo T, Nakata M, Sakurai A, Kuwata H, Kawabata S]
通讯作者:
Kawabata S
感染・炎症・免疫, タイでコレラに挑む
感染、炎症和免疫,应对泰国霍乱
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[岡田和久, 浜田茂幸]
通讯作者:
浜田茂幸
Streptococcus suis 全血清型の莢膜関連遺伝子群の解析
猪链球菌所有血清型荚膜相关基因分析
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[大倉正稔]
通讯作者:
大倉正稔
Streptcoccus pyogenes inhibits to form complement membrane attack complex
化脓性链球菌抑制补体膜攻击复合物的形成
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[寺尾豊, 川端重忠]
通讯作者:
川端重忠
Streptococcus pyogenes inhibits to form complement membrane attack complex
化脓性链球菌抑制补体膜攻击复合物的形成
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[寺尾豊, 川端重忠]
通讯作者:
川端重忠
共 63 条
Identification of factors enabling Group A Streptococcus reside without virulence
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批准号:24659197
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2012
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负责人:HAMADA Shigeyuki
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依托单位:
Tiling array analysis of transcriptional regulators in genus Streptococcus
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批准号:19390468
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.56万
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财政年份:2007
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负责人:HAMADA Shigeyuki
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依托单位:
Molecular analysis of the developmental mechanism of periodontal and oral diseases by the genome analysis of oral biofilm.
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批准号:17390485
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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财政年份:2005
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负责人:HAMADA Shigeyuki
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依托单位:
Molecular analysis of streptococcal infections diseases by the functional genomics.
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批准号:14207074
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.12万
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财政年份:2002
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负责人:HAMADA Shigeyuki
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依托单位:
Preventive strategy of marginal periodontitis by antimicrobial and adhesion-inhibitory basic peptides and protamines.
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批准号:11557132
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.38万
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财政年份:1999
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负责人:HAMADA Shigeyuki
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依托单位:
Molecular analyses on Streptococcus pyogenes adherence to and invasion of pharyngeal epithelial cells
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批准号:11307039
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$9.56万
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财政年份:1999
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负责人:HAMADA Shigeyuki
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依托单位:
Development studies on specific inhibitors of adherence of periodontal pathogen based on the etiology
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批准号:09557139
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.3万
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财政年份:1997
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负责人:HAMADA Shigeyuki
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依托单位:
Mechanisms of adherence of P.gingivalis to matrix proteins via fimbrial cryptie receptor
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批准号:08457480
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.67万
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财政年份:1996
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负责人:HAMADA Shigeyuki
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依托单位:
Development of mutacin MT6223 from Streptococcus sobrinus as an anti-caries agent
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批准号:06557099
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$5.95万
-
财政年份:1994
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负责人:HAMADA Shigeyuki
-
依托单位:
Bacterial endotoxic substances from periodontopathic bacteria and their effects on host cells
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批准号:05454192
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1993
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负责人:HAMADA Shigeyuki
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依托单位:
Studies on the pathogenesis of periodontal disease from the viewpoint of local immunity
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批准号:01480430
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.29万
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财政年份:1989
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负责人:HAMADA Shigeyuki
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依托单位:
Immunobiological Studies on the Pathogenic Mechanisms of Periodontal Disease
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批准号:01044085
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$7.23万
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财政年份:1989
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负责人:HAMADA Shigeyuki
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依托单位:
DEVELOPMENT OF LATEX AGGLUTINATION TEST FOR SPECIFIC DETECTION OF BACTEROIDES GINGIVALIS
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批准号:63870072
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$3.58万
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财政年份:1988
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负责人:HAMADA Shigeyuki
-
依托单位:
Gene Cloning of Virulence Factors of Streptococcus mutans
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批准号:61480395
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$1.92万
-
财政年份:1986
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负责人:HAMADA Shigeyuki
-
依托单位:
海外基金