An alternative interferon inducing pathway predicted through phylogenetic analyses

通过系统发育分析预测的另一种干扰素诱导途径

• 批准号: 24659214
• 负责人: SEYA Tsukasa
• 金额: $ 2.5万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659214/
• 关键词: 自然免疫; パターン認識レセプター; インターフェロン

Two membrane proteins having N-terminal extracellular domain Ig (immunoglobulin domain) and C-terminal Toll-IL-1 homology domain (TIR) were identified from the zebrafish database. We called these proteins Ig-TIR. We have cloned the cDNAs of these proteins and their functional properties were determined with overexpression and siRNA analysis using rainbow trout cell lines. We could not detect any activity affecting NF-kB activation, IFN induction or cytokine assays. We suppose that the Ig-TIR proteins have functions other than the known TLR proteins that sense microbial pattern molecules.

从斑马鱼数据库中鉴定了两种膜蛋白，其具有N-末端胞外结构域IG（免疫球蛋白结构域）和C-末端Toll-IL-1同源结构域（TIR）。我们将这些蛋白质称为Ig-TIR。我们克隆了这些蛋白质的cDNA，并使用虹鳟鱼细胞系通过过表达和siRNA分析确定了它们的功能特性。我们不能检测到任何影响NF-kB活化、IFN诱导或细胞因子测定的活性。我们假设Ig-TIR蛋白具有不同于已知的TLR蛋白的功能，TLR蛋白感测微生物模式分子。

项目成果

TAMable tumor-associated macrophages in response to innate RNA sensing.

• DOI: 10.4161/onci.19894
• 发表时间: 2012-09-01
• 期刊: Oncoimmunology
• 影响因子: 7.2
• 作者: Seya T;Shime H;Matsumoto M
• 通讯作者: Matsumoto M

The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model

在小鼠感染模型中，类浆细胞和 CD4 树突状细胞中的 MyD88 通路主要触发针对麻疹病毒的 I 型 IFN 产生

• 发表时间: 2013
• 期刊: J Immunol
• 影响因子: 4.4
• 作者: Takaki H;Takeda M;Tahara M;Shingai M;Oshiumi H;Matsumoto M;Seya T.
• 通讯作者: Seya T.

Hepatitis C Virus Infection Induces Inflammatory Cytokines and Chemokines Mediated by the Cross Talk between Hepatocytes and Stellate Cells

• DOI: 10.1128/jvi.00974-13
• 发表时间: 2013-07-01
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Nishitsuji, Hironori;Funami, Kenji;Shimotohno, Kunitada
• 通讯作者: Shimotohno, Kunitada

IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection

• DOI: 10.4049/jimmunol.1301459
• 发表时间: 2014-03-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Okamoto, Masaaki;Oshiumi, Hiroyuki;Seya, Tsukasa
• 通讯作者: Seya, Tsukasa

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

• DOI: 10.1073/pnas.1113099109
• 发表时间: 2012-02-07
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Shime, Hiroaki;Matsumoto, Misako;Seya, Tsukasa
• 通讯作者: Seya, Tsukasa