A metabolomics study of children with neurodevelopmental problems due to dioxin exposure

二恶英暴露导致神经发育问题儿童的代谢组学研究

• 批准号: 24659306
• 负责人: NAKAGAWA Hideaki
• 金额: $ 2.41万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659306/
• 关键词: ダイオキシン; メタボロミクス; 尿検査; 脳神経発達; 自閉症スペクトラム障害; 早期指標; ベトナム; 社会情動発達; 小児

In a hot spot of dioxin contamination in Vietnam, we examined social emotional behaviors by autism spectrum rating scale (ASRS) of 3-year-old children and found that the high TCDD exposed group showed higher ASRS scores as compared with the lower exposed groups, suggesting autistic traits. Then, we analyzed urinary metabolomes of the high TCDD group and age and gender matched low exposure groups and detected candidate compound to discriminate these high and low TCDD groups. Urinary histidine and tryptophan were selected for good negative markers and significant decreased levels of these amino acids were observed in the high TCDD group. However, no significant correlation was observed between dioxin levels in breast milk and urinary levels of histidine and tryptophan in 68 6-month-old infants living in another hot spot in Vietnam. They might be too young to detect alteration of urinary amino acids. We need to follow-up them for longer time and collect more number of urine specimens.

在越南二恶英污染的热点地区，我们通过自闭症谱系评定量表（ASRS）对3岁儿童的社会情绪行为进行了检查，发现TCDD高暴露组比低暴露组表现出更高的ASRS分数，表明存在自闭症特征。然后，我们分析了高 TCDD 组以及年龄和性别匹配的低暴露组的尿液代谢组，并检测了候选化合物来区分这些高 TCDD 组和低 TCDD 组。选择尿组氨酸和色氨酸作为良好的阴性标记，在高 TCDD 组中观察到这些氨基酸的水平显着降低。然而，在越南另一个热点地区的 68 名 6 个月大婴儿中，母乳中的二恶英含量与尿中组氨酸和色氨酸含量之间没有观察到显着相关性。他们可能太年轻，无法检测尿氨基酸的变化。我们需要对他们进行更长时间的随访，收集更多的尿液样本。

项目成果

ダイオキシン環境曝露の出生児の脳神経発達に与える影響 : ベトナムにおける小児コホート3年間の追跡

二恶英环境暴露对新生儿大脑发育的影响：越南儿科队列的 3 年随访

• 发表时间: 2013
• 作者: 西条旨子、Pham The Tai;Nguyen Thi Nguyet Anh;Tran Ngoc Nghi,丸銭笑子,中川秀昭,森河裕子,岡本理恵,城戸照彦;Hoang Van Luong;Tran Hai Anh;Phan Thanh Phuong,西条寿夫
• 通讯作者: Phan Thanh Phuong,西条寿夫

Relationships between food intake and dioxin concentrations in breast milk of mothers living in a hot spot of dioxin contamination in Vietnam

生活在越南二恶英污染热点地区的母亲的食物摄入量与母乳中二恶英浓度的关系

• 发表时间: 2013
• 作者: Nguyen Thi Nguyet Anh;Pham The Tai;Nishijo M;Maruzeni S;Anh TH;Dam N;Luong HV;Morikawa Y;Nakagawa H;Nishijo H.
• 通讯作者: Nishijo H.

ベトナムの高汚染地域に居住する3歳児におけるダイオキシン暴露と自閉症傾向

越南高污染地区3岁儿童二恶英暴露与自闭症趋势

• 发表时间: 2014
• 作者: 西条旨子、Tai PT;Anh NTN;Tran Ngoc Nghi中川秀昭、城戸照彦、西条寿夫
• 通讯作者: Tran Ngoc Nghi中川秀昭、城戸照彦、西条寿夫

Effects of perinatal exposure to dioxins on neurodevelopment in Vietnamese children at 3 years of age.

围产期接触二恶英对 3 岁越南儿童神经发育的影响。

• 发表时间: 2013
• 作者: Satoh M;Kato N;Hosaka M;Sato H;Imai Y;et al.;Tran Ngoc Nghi
• 通讯作者: Tran Ngoc Nghi

Perinatal dioxin exposure and neurodevelopment of children aged 3 years–A follow up study in Vietnam

围产期二恶英暴露与 3 岁儿童神经发育——越南跟踪研究

• 发表时间: 2013
• 作者: Tai PT;Nishijo M;Anh NTN;Maruzeni S;Nakagawa H;Luong HV;Anh TH;Nhat TV;Thanh TT;Phuong PT;Son LK;Morikawa Y;Kido T;Nishijo H.
• 通讯作者: Nishijo H.