An epidemiological study of maternal dioxins exposure and infant growth

母亲二恶英暴露与婴儿生长的流行病学研究

• 批准号: 16590489
• 负责人: NAKAGAWA Hideaki
• 金额: $ 1.92万
• 依托单位: KANAZAWA MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590489/
• 关键词: Dioxin; the next generation; infant growth; epidemiological survey; food preference; head circumference; fish; vegetable; 乳幼児; 社会的要因; 生活環境; 血圧; 血清コレステロール; 出生体重; 疫学

In this study, we examined the relationship between infant growth and the concentration of dioxins in breast milk as an indicator of maternal exposure. A total of 44 milk samples were obtained on the 5-8^<th> postpartum day from mothers in Japan exposed to dioxins at the background level. The levels of 7 dioxins and 10 furan isomers were measured in each milk sample using an HR-GC/MS system. The levels of isomers in these subjects were lower than those in urban areas, showing similar isomer pattern as other areas. The HxCDD concentration negatively correlated with newborn head circumference and meight, even after adjustment for gestational age, infant sex, parity and other confounding factors. However, there was significant positive correlation between infant height at 1 month old and HpCDF in breast milk, which was related to amount and frequency of fish intake. Therefore, maternal fish intake might help infant growth after birth due to breast feeding, even if dioxins and frans were increased in breast milk. On the other hand, HxCDD in breast milk in mothers who preferred to take a lot of green vegetable was higher than that in mothers who didn't eat much. These facts suggested that dioxins/frans contamination from vegetable due to agricultural chemicals might affect on fetal development.

在这项研究中，我们研究了婴儿生长和母乳中二恶英浓度之间的关系，作为母亲暴露的指标。在产后5-8天，<th>从日本暴露于二恶英背景水平的母亲中共获得44份乳汁样本。使用HR-GC/MS系统测量每个牛奶样品中的7种二恶英和10种呋喃异构体的水平。结果表明，受检者体内异构体水平低于城市人群，呈现与其他地区相似的异构体分布模式。HxCDD浓度与新生儿头围和体重呈负相关，即使在校正了胎龄、婴儿性别、产次和其他混杂因素后也是如此。但1月龄婴儿身高与母乳中HpCDF呈显著正相关，且与鱼类摄入量和频率有关。因此，即使母乳中的二恶英和frans增加，母亲摄入鱼类可能有助于婴儿出生后由于母乳喂养而生长。另一方面，喜欢吃大量绿色蔬菜的母亲母乳中的HxCDD高于不喜欢吃蔬菜的母亲。这些事实表明，二恶英/frans污染的蔬菜，由于农业化学品可能会影响胎儿的发育。