An epidemiological study of maternal dioxins exposure and infant growth

在这项研究中，我们研究了婴儿生长和母乳中二恶英浓度之间的关系，作为母亲接触二恶英的指标。在产后5 ~ 8天，从暴露于背景水平二恶英的日本母亲中采集了44份牛奶样本。采用HR-GC/MS系统测定了7种二恶英和10种呋喃异构体的含量。这些研究对象的异构体水平低于城市地区，表现出与其他地区相似的异构体模式。HxCDD浓度与新生儿头围和体重呈负相关，即使在调整胎龄、婴儿性别、胎次等混杂因素后也是如此。然而，婴儿1月龄身高与母乳中HpCDF呈显著正相关，这与鱼的摄入量和频率有关。因此，母亲摄入鱼类可能有助于婴儿出生后的生长，因为母乳喂养，即使二恶英和麸质在母乳中增加。另一方面，喜欢吃大量绿色蔬菜的母亲母乳中的HxCDD高于不吃太多蔬菜的母亲。这些事实表明，由于农用化学品的污染，蔬菜中的二恶英/呋喃可能会影响胎儿发育。

In this study, we examined the relationship between infant growth and the concentration of dioxins in breast milk as an indicator of maternal exposure. A total of 44 milk samples were obtained on the 5-8^<th> postpartum day from mothers in Japan exposed to dioxins at the background level. The levels of 7 dioxins and 10 furan isomers were measured in each milk sample using an HR-GC/MS system. The levels of isomers in these subjects were lower than those in urban areas, showing similar isomer pattern as other areas. The HxCDD concentration negatively correlated with newborn head circumference and meight, even after adjustment for gestational age, infant sex, parity and other confounding factors. However, there was significant positive correlation between infant height at 1 month old and HpCDF in breast milk, which was related to amount and frequency of fish intake. Therefore, maternal fish intake might help infant growth after birth due to breast feeding, even if dioxins and frans were increased in breast milk. On the other hand, HxCDD in breast milk in mothers who preferred to take a lot of green vegetable was higher than that in mothers who didn't eat much. These facts suggested that dioxins/frans contamination from vegetable due to agricultural chemicals might affect on fetal development.