Relationship of the Intake of Selenium and Antioxidant Vitamins to Serum Lipid peroxide

硒和抗氧化维生素摄入量与血清过氧化脂质的关系

• 批准号: 10670368
• 负责人: NAKAGAWA Hideaki
• 金额: $ 2.05万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670368/
• 关键词: lipid peroxide; selenium; antioxidant vitamins; vitamin E; vitamin C; vitamin A; epidemiology; 栄養調査

The relationship of the intake of selenium and antioxidant vitamins to serum lipid peroxide (TBA value) was investigated using a high-quality nutritional survey and blood examination among 300 apparently healthy men and women aged 40-59 years. The main results were as follows :1. Serum lipid peroxide (LPO) was higher in men and in older subjects. The increasing tendency by age was independent from other factors.2. The intake density (intake per 1000 kcal energy intake) of vitamin C was independently and inversely related to serum LPO.Vitamin C was likely to inhibit lipid peroxidation in human body.3. Serum alpha-tocopherol concentration was not related to serum LPO.4. Vitamin A intake was not inversely related to serum LPO.Serum vitamin A concentration was positively related to serum LPO, which was likely to be confounded by serum vitamin A increase through fatty liver.5. Selenium intake was not inversely related to serum LPO.Because the estimation of selenium intake was not sufficient in this study, The establishment of selenium consumption table or the determination of blood selenium concentration would be necessary.6. Serum gamma-GTP was strongly and positively related to serum LPO, independently from alcohol intake or body mass. The production of LPO would increase through liver cell damage such as inflammation in liver.These findings would contribute to the better assessment of oxidative stress in disease prevention and to establishing methods for the usage of antioxidants.

采用高质量营养调查和血液检查方法，对300名40-59岁表面健康的男女进行了硒和抗氧化维生素摄入量与血清过氧化脂质（TBA值）的关系研究。主要研究结果如下：1.血清过氧化脂质（LPO）在男性和老年受试者中较高。随年龄增长的趋势与其他因素无关.维生素C的摄入密度（每1000千卡能量摄入量）与血清LPO呈独立负相关，维生素C可能具有抑制人体脂质过氧化作用.血清α-生育酚浓度与血清LPO无关。维生素A摄入量与血清LPO无负相关关系，血清维生素A浓度与血清LPO呈正相关，这可能被脂肪肝引起的血清维生素A升高所混淆.硒摄入量与血清LPO无负相关关系，由于本研究对硒摄入量的估算还不够充分，因此有必要建立硒摄入量表或测定血硒浓度.血清γ-GTP与血清LPO呈强正相关，与酒精摄入量或体重无关。这些发现将有助于更好地评估氧化应激在疾病预防中的作用，并有助于建立抗氧化剂的使用方法。