Effect of shift work on cardio-vascular function -A comparison between normotensive and hypertensive subjects-

轮班工作对心血管功能的影响-正常血压与高血压受试者的比较-

• 批准号: 11670391
• 负责人: NAKAGAWA Hideaki
• 金额: $ 1.98万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670391/
• 关键词: shift work; night-shift; blood pressure; ambulatory blood pressure; heart rate; circadian rhythm; 高血圧; 身体活動

Aims of this study are to investigate effects of shift work on blood pressure and cardio-vascular function, and to identify whether there are differences in such effects between normotensive and hypertensive subjects. The subjects of this study were 10 normotensive men, 9 hypertensive men without medication, and 9 men under anti-hypertensive medication. Ambulatory blood pressure (ABP) during 24 hours in daytime shift and in nighttime shift was recorded by the non-invasive devise (Nihon-Koden). Also physical activities, heart rates and postures were measured by lightweight portable monitor (GMS, Activetracer AC301).Results; (1) Blood pressures were changed according to activity level in both daytime and nighttime. (2) Among normotensive subjects, the basal blood pressures (the lowest blood pressure during sleeping) were higher in nighttime shift than in daytime shift with statistical significance. (3) The mean blood pressures during work-time weren't different between daytime shift and nighttime shift for normotensive subjects arid hypertensive subjects. (4) Among subjects under anti-hyoertensive medication, the blood pressures immediately after nighttime work were higher than that after daytime work. (5) Among the subjects with hypertension, the standard deviations of blood pressure during working time were larger in nighttime shift than in daytime shift. (6) There are positive linear regression between blood pressure, heart rate and activities measured by accelometer. The heart rates during night shift decreased compared with those during daytime shift.These results suggested that nighttime shift had effects on cardio-vascular function to both normotensive and hypertensiove subjects. Among hypertensive subjects, the effects of extrinsic stimulation seemed to be larger during nighttime shift than daytime shift. Also among normotensive subjects, we found higher blood pressure level during sleep between nighttime shifts than daytime shift.

本研究的目的是探讨轮班工作对血压和心血管功能的影响，并确定这种影响在正常和高血压受试者之间是否存在差异。研究对象为10名正常血压男性、9名未服药的高血压男性和9名正在服药的降压男性。采用无创血压仪（Nihon-Koden）记录白班和夜班24小时动态血压（ABP）。同时用轻便便携式监测仪（GMS, Activetracer AC301）测量身体活动、心率和姿势。(1)白天和夜间血压随活动量变化。(2)在血压正常者中，夜班的基础血压（睡眠时最低血压）高于白班，差异有统计学意义。(3)正常血压组和高血压组的平均工作时间血压在白班和夜班之间没有差异。(4)服用降压药的受试者夜间工作后立即血压高于白天工作后。(5)高血压被试中，夜班工作时间血压的标准差大于白班。(6)加速度计测量的血压、心率与活动量之间存在正线性回归。与白班相比，夜班的心率有所下降。这些结果表明，夜班对正常血压和高血压受试者的心血管功能都有影响。在高血压受试者中，外部刺激的影响似乎在夜班比白班更大。此外，在血压正常的受试者中，我们发现夜班之间的睡眠血压水平高于白班。