Development of novel therapeutic strategy for atherosclerotic vascular diseases via the activation of natural killer T cells
Development of novel therapeutic strategy for atherosclerotic vascular diseases via the activation of natural killer T cells
批准号:
24659379
负责人:
TSUTSUI Hiroyuki
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 --
中文摘要
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英文摘要
The development and progression of atherosclerosis involves complex inflammatory processes between hematocytes and vascular tissues. Natural killer T (NKT) cells, a unique subset of T lymphocytes that recognize glycolipid antigens and secrete a large amount of TH1/TH2 cytokines, play a crucial role in regulating tissue inflammation. The present study demonstrated that inflammatory process regulated via NKT cells is involved in atherosclerotic lesions and NKT cells may be the novel therapeutic targets in atherosclerotic vascular diseases.
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Invariant natural killer T cells are involved in the development ofexperimental abdominal aortic aneurysm and dissection in apolipoprotein-E deficient mice
恒定自然杀伤 T 细胞参与载脂蛋白 E 缺陷小鼠实验性腹主动脉瘤和夹层的形成
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Ishimori N, Tokuhara S, Nozawa A, Saito A, Tsutsui H]
通讯作者:
Tsutsui H
Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance.
II型NKT细胞通过介导脂肪组织炎症,脂肪性肝炎和胰岛素抵抗来刺激饮食诱导的肥胖。
DOI:
10.1371/journal.pone.0030568
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Satoh M, Andoh Y, Clingan CS, Ogura H, Fujii S, Eshima K, Nakayama T, Taniguchi M, Hirata N, Ishimori N, Tsutsui H, Onoé K, Iwabuchi K]
通讯作者:
Iwabuchi K
Invariant natural killer T cells are involved in the development of experimental abdominal aortic aneurysm and dissection in apolipoprotein-E deficient mice.
不变的自然杀伤 T 细胞参与载脂蛋白 E 缺陷小鼠实验性腹主动脉瘤和夹层的形成。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Ishimori N, Tokuhara S, Nozawa A, Saito A, Tsutsui H]
通讯作者:
Tsutsui H
Activation of natural killer T cells ameliorates the development of angiotensin II-mediated abdominal aortic aneurysm formation in obese ob/ob mice.
自然杀伤 T 细胞的激活可改善肥胖 ob/ob 小鼠中血管紧张素 II 介导的腹主动脉瘤形成。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Saito A, Ishimori N, Tokuhara S, Nozawa A, Nishikawa M, Tsutsui H]
通讯作者:
Tsutsui H
知のフロンティア北海道大学の研究者は、いま第2号
知识前沿 北海道大学研究人员现在位居第二
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Katoh S, Honda S, Watanabe T, Suzuki S, Ishino M, Kitahara T, Funayama A, Netsu S, Sasaki T, Shishido T, Miyamoto T, Sadahiro M, Kubota I., 筒井裕之]
通讯作者:
筒井裕之
共 9 条
Development of novel preventive strategy for post-infarct cardiac rupture via the regulation of inflammatory process by the activation of natural killer T cells
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批准号:25670378
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:TSUTSUI Hiroyuki
-
依托单位:
Role of natural killer T cells in myocardial remodeling and its therapeutic implication.
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批准号:24390192
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
-
财政年份:2012
-
负责人:TSUTSUI Hiroyuki
-
依托单位:
Study on the molecular mechanisms and treatment for mitochondrial regulation in cardiac remodeling
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批准号:21390236
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.48万
-
财政年份:2009
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负责人:TSUTSUI Hiroyuki
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依托单位:
Analysis of the role of mitochondrial transcription factor in cardiovascular diseases and the development of novel therapeutic strategies
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批准号:17390223
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.5万
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财政年份:2005
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负责人:TSUTSUI Hiroyuki
-
依托单位:
Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure
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批准号:14370230
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.9万
-
财政年份:2002
-
负责人:TSUTSUI Hiroyuki
-
依托单位:
Mechanisms of oxygen radical generation in the mitochondria from the failing hearts
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批准号:12670676
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2000
-
负责人:TSUTSUI Hiroyuki
-
依托单位:
Role of myocyte nitric oxide in the contractile dysfunction in heart failure.
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批准号:09670724
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
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财政年份:1997
-
负责人:TSUTSUI Hiroyuki
-
依托单位:
Pathophysiology of diastolic dysfunction in hypertrophied hearts-Role of myocyte cytoskeleton-
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批准号:07670789
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.54万
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财政年份:1995
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负责人:TSUTSUI Hiroyuki
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依托单位:
海外基金