Role of myocyte nitric oxide in the contractile dysfunction in heart failure.

肌细胞一氧化氮在心力衰竭收缩功能障碍中的作用。

• 批准号: 09670724
• 负责人: TSUTSUI Hiroyuki
• 金额: $ 1.66万
• 依托单位: KYUSHU UNIVERSITY FACULTY OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670724/
• 关键词: Heart failure; Nitric oxide; Myocyte; Contractility; beta-adrenergic receptor

Heart failure is associated with the contractile dysfunction and theimpaired responsiveness to beta-adrenergic stimulation at the myocyte level of unknown causes. Heart failure increased nitric oxide (NO) in the myocardium, which was responsible for the diminished contractile responses to beta-adrenergic stimulation. The association of NO and contractile abnormalities was recognized in the animal model of failing heart and increased NO induction might have pathophysiological significance for the contractile defects in congestive heart failure.

心力衰竭与收缩功能障碍和不明原因的肌细胞水平对β-肾上腺素能刺激的反应性受损有关。心力衰竭会增加心肌中的一氧化氮（NO），这是导致β-肾上腺素能刺激的收缩反应减弱的原因。在心脏衰竭的动物模型中，NO 与收缩异常之间的关联得到了认可，NO 诱导的增加可能对充血性心力衰竭的收缩缺陷具有病理生理学意义。

项目成果

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Ishibashi Y，Urabe Y，Tsutsui H，Kinukawa S，Sugimachi M，Takahashi M，Yamamoto S，Takawa H，Sunakawa K，Takeshita A：“碱性成纤维细胞生长因子（bFGF）对成年大鼠心肌细胞的负性肌力作用”循环。

Yamamoto S, Tsutsui H, et al: "Role of myocyte nitric oxide in β-adrenergic hyporesponsiveness in heart failure." Circulation. 95. 1111-1114 (1997)

Yamamoto S、Ttsutsui H 等人：“心肌细胞一氧化氮在心力衰竭中 β-肾上腺素能低反应中的作用。循环”。

Yamamoto S,Tsutsui H,Tagawa H,Saito K,Takahashi M,Tada M,Yamamoto M,Katoh M,Egashira K,Takeshita A: "Role of myocyte nitric oxide in beta-adrenergic hyporesponsiveness in heart failure" Circulation. 95. 1111-1114 (1997)

Yamamoto S，Ttsutsui H，Takawa H，Saito K，Takahashi M，Tada M，Yamamoto M，Katoh M，Egashira K，Takeshita A：“肌细胞一氧化氮在心力衰竭β-肾上腺素能低反应性中的作用”循环。

Takahashi M,Tsutsui H,Tagawa H,Kinugawa S,Ishibashi Y,Igarashi-Saito K,Imanaka-Yoshida K,Takeshita A: "Microtubules are Involved for the Initiation of Cardiac Hypertrophy during Pressure Overload" Am J Physiol. 275. H341-H348 (1998)

Takahashi M、Tsutsui H、Takawa H、Kinukawa S、Ishibashi Y、Igarashi-Saito K、Imanaka-Yoshida K、Takeshita A：“微管参与压力过载期间心脏肥大的启动”Am J Physiol。