Pathophysiology of diastolic dysfunction in hypertrophied hearts-Role of myocyte cytoskeleton-

肥厚心脏舒张功能障碍的病理生理学-心肌细胞骨架的作用-

• 批准号: 07670789
• 负责人: TSUTSUI Hiroyuki
• 金额: $ 1.54万
• 依托单位: KYUSHU UNIVERSITY FACULTY OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670789/
• 关键词: Hypertrophy; Heart failure; Cytoskeleton; Microtubules; Viscosity; Elasticity; 肥大心; 不全心; 細胞骨格

1) Role of microtubules for the myocyte contractile dysfunction during cardiac hypertrophyThe progressive increase of microtubule density during LV hypertrophy due to persistent pressure overloading to the myocardium may cause the consequent myocyte contractile dysfunction.2) Role of microtubules in the viscoelastic properties of the myocardiumMicrotubule alterations could also affect the contractile force development in the multicellular tissue preparations, which might allow us to extend the findings obtained at the cellular level to the ventricular contractile performance in vivo. The increased microtubules conld also contribute to the increased viscosity of the myocardium. Therefor, microtubules are of especial importance in cardiac muscle contractility because the alterations of these elements might well explain the performance changes noted in the hypertrophied myocardium.

1) 微管在心脏肥大期间心肌细胞收缩功能障碍中的作用左心室肥厚期间，由于心肌持续压力超负荷，微管密度逐渐增加，可能导致随后的心肌细胞收缩功能障碍。2) 微管在心肌粘弹性特性中的作用微管改变也可能影响心肌收缩力的发展。 多细胞组织制剂，这可能使我们能够将在细胞水平上获得的发现扩展到体内心室收缩性能。微管的增加还导致心肌粘度增加。因此，微管在心肌收缩力中特别重要，因为这些元素的改变可以很好地解释肥厚心肌中注意到的性能变化。

项目成果

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Tsutsui H 等人：“压力超负荷心脏肥大中肌浆网钙储存蛋白的变化。”