Study on the molecular mechanisms and treatment for mitochondrial regulation in cardiac remodeling

线粒体调控心脏重构的分子机制及治疗研究

• 批准号: 21390236
• 负责人: TSUTSUI Hiroyuki
• 金额: $ 11.48万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390236/
• 关键词: 心筋リモデリング; 心不全; ミトコンドリア; DNA; 転写因子

Mitochondrial oxidative stress leads to a catastrophic cycle of mitochondrial DNA damage as well as functional decline, higher oxidative stress, and cellular injury. Oxidative stress activates a broad variety of hypertrophy signaling kinases and transcription factors and mediate apoptosis. It also stimulates cardiac fibroblast proliferation and activates the matrix metalloproteinases, leading to the extracellular matrix remodeling. These cellular events are involved in the development and progression of maladaptive myocardial remodeling and failure.

线粒体氧化应激导致线粒体DNA损伤的灾难性循环，以及功能衰退、更高的氧化应激和细胞损伤。氧化应激可激活多种肥大信号通路和转录因子，并介导细胞凋亡。它还刺激心脏成纤维细胞增殖，激活基质金属蛋白酶，导致细胞外基质重塑。这些细胞事件参与了适应性不良心肌重塑和衰竭的发生和发展。

项目成果

酸化ストレス,高血圧ナビゲーター

氧化应激、高血压导航

• 发表时间: 2011
• 作者: Okumura S;Cai W;Jin M;Bai Y;Tsunematsu T;HidakaY;Kurotani R;Ishikawa Y;絹川真太郎,筒井裕之
• 通讯作者: 絹川真太郎,筒井裕之

Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenior cell mobilization.

Syndecan-4 缺陷通过调节血管平滑肌细胞增殖和血管祖细胞动员来限制血管损伤后的新内膜形成。

• 发表时间: 2010
• 期刊: Arterioscler Thromb Vasc Biol
• 作者: Ikesue M.;et al
• 通讯作者: et al

Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction

• DOI: 10.1152/japplphysiol.90368.2008
• 发表时间: 2009-04-01
• 期刊: JOURNAL OF APPLIED PHYSIOLOGY
• 影响因子: 3.3
• 作者: Suga, Tadashi;Okita, Koichi;Tsutsui, Hiroyuki
• 通讯作者: Tsutsui, Hiroyuki

Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice

• DOI: 10.1111/j.1440-1789.2009.01086.x
• 发表时间: 2010-08-01
• 期刊: NEUROPATHOLOGY
• 影响因子: 2.3
• 作者: Hokari, Masaaki;Kuroda, Satoshi;Iwasaki, Yoshinobu
• 通讯作者: Iwasaki, Yoshinobu

心不全における心腎連関

心力衰竭中的心肾联系

• 发表时间: 2010
• 作者: Hyodo M;Makino S;Awaji Y;Sakurada Y;Ohkubo T;Murata M;Fukuda K;Tsuda M;筒井裕之
• 通讯作者: 筒井裕之