Identification of cytotoxic T lymphocyte responses to lipopeptides in human immunodeficiency virus-infected patients.

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A new pathway for host defense has recently been identified in the monkey model of AIDS, in which lipopeptide-specific cytotoxic T lymphocytes expand and combat against infection. However, it remains to be determined whether such T cell responses may exist in humans. In this study, we found for the first time that lipopeptide-specific T cells existed in the circulation of a fraction of human immunodeficiency virus-infected patients, capable of producing interferon-gamma, one of the major host-protective factors.