CD1/lipid immunity-based vaccines against AIDS

基于 CD1/脂质免疫的艾滋病疫苗

• 批准号: 22659188
• 负责人: SUGITA Masahiko
• 金额: $ 2.16万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659188/
• 关键词: 感染症防御学; リポペプチド; エイズ; ワクチン; CD1

Effective protein vaccines against infection with human immunodeficiency virus remain to be established. The difficulties arise from the frequent escape mutations, and thus, identification of T cell epitopes that admit of no arbitrary mutations is crucial. We have identified cytotoxic T cell responses to myristoylated Nef peptides(lipopeptides) both in cell culture and in the monkey model of human AIDS. Because the protein myristoylation occurs in highly conserved amino acid sequences and is critical for virulence, the present study underscored the possibility that lipopeptides could be an ideal target for anti-AIDS vaccines.

针对人类免疫缺陷病毒感染的有效蛋白质疫苗仍有待建立。困难源于频繁的逃逸突变，因此，鉴定不允许任意突变的 T 细胞表位至关重要。我们在细胞培养物和人类艾滋病猴模型中鉴定了对肉豆蔻酰化 Nef 肽（脂肽）的细胞毒性 T 细胞反应。由于蛋白质肉豆蔻酰化发生在高度保守的氨基酸序列中，并且对于毒力至关重要，因此本研究强调了脂肽可能成为抗艾滋病疫苗的理想靶标的可能性。

项目成果

Nef蛋白質のミリスチン酸修飾をモニターする新たな免疫システム

监测 Nef 蛋白肉豆蔻酸修饰的新免疫系统

• 发表时间: 2011
• 作者: 森田大輔;五十嵐樹彦;堀池麻理子;森直樹;杉田昌彦
• 通讯作者: 杉田昌彦

Cutting Edge: T Cells Monitor N-Myristoylation of the Nef Protein in Simian Immunodeficiency Virus-Infected Monkeys

• DOI: 10.4049/jimmunol.1101216
• 发表时间: 2011-07-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Morita, Daisuke;Igarashi, Tatsuhiko;Sugita, Masahiko
• 通讯作者: Sugita, Masahiko