Establishment of a novel method for brain activity dependent neuroimaging

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In order to establish a novel method for a neuronal activity-dependent neuroimaging analysis, a non-metal imaging device was fabricated to record the neurophysiological changes and PET scans simultaneously. The numerical model-based attenuation correction was implemented to correct for the lower counts induced by the device. The radioactivity in the blood quickly achieved a steady state after the intravenous injection of FDG combining bolus injection and continuous infusion, whereas it was continuously increased in the brain. Moreover, the electrical stimulation-related functional neuroimages were reconstructed by a trigger driven gating method in which every 5-sec PET list mode data were sorted into a gate sinogram according to a time-stamp driven by a trigger signal which was synchronized with the electrical stimulation.