Establishment of a novel method for brain activity dependent neuroimaging

建立大脑活动依赖性神经成像新方法

• 批准号: 24659574
• 负责人: CUI Yilong
• 金额: $ 2.41万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659574/
• 关键词: ＰＥＴ; 脳機能画像; 神経活動; 脳機能画像解析; PET

In order to establish a novel method for a neuronal activity-dependent neuroimaging analysis, a non-metal imaging device was fabricated to record the neurophysiological changes and PET scans simultaneously. The numerical model-based attenuation correction was implemented to correct for the lower counts induced by the device. The radioactivity in the blood quickly achieved a steady state after the intravenous injection of FDG combining bolus injection and continuous infusion, whereas it was continuously increased in the brain. Moreover, the electrical stimulation-related functional neuroimages were reconstructed by a trigger driven gating method in which every 5-sec PET list mode data were sorted into a gate sinogram according to a time-stamp driven by a trigger signal which was synchronized with the electrical stimulation.

为了建立一种新的神经元活动依赖性神经成像分析的方法，制造了一种非金属成像装置，以同时记录神经生理学的变化和PET扫描。 实施了基于数值模型的衰减校正，以纠正设备引起的较低计数。 静脉注射FDG结合推注和连续输注后，血液中的放射性迅速达到了稳定状态，而大脑中的放射性则不断增加。 此外，通过触发驱动的门控方法重建了与电刺激相关的功能性神经图像，其中每个5-SEC PET列表模式数据都根据由触发信号驱动的时间戳记将与电刺激同步的触发信号驱动的时间戳记分类。

项目成果

Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography

11C 标记的 Antiprion GN8 衍生物的合成及其脑摄取的正电子发射断层扫描评估

• DOI: 10.1002/cmdc.201300167
• 发表时间: 2013
• 期刊: ChemMedChem
• 影响因子: 3.4
• 作者: Tsutomu Kimura;Takeo Sako;Siqin;Junji Hosokawa-Muto;Yi Long Cui;Yasuhiro Wada;Yosky Kataoka;Hisashi Doi;Suehiro Sakaguchi;Masaaki Suzuki;Yasuyoshi Watanabe;Kazuo Kuwata
• 通讯作者: Kazuo Kuwata

Neuroinflammation in Animal Models of Fatigue

• DOI: 10.3233/nib-130073
• 发表时间: 2013-01-01
• 期刊: ADVANCES IN NEUROIMMUNE BIOLOGY
• 作者: Kataoka, Yosky;Yamato, Masanori;Cui, Yilong
• 通讯作者: Cui, Yilong

Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rats

• DOI: 10.1002/syn.21644
• 发表时间: 2013-07-01
• 期刊: SYNAPSE
• 影响因子: 2.3
• 作者: Fujita, Satoshi;Kato, Risako;Kobayashi, Masayuki
• 通讯作者: Kobayashi, Masayuki

Functional anatomy of gustation in the alert rat revealed by positron emission tomography.

正电子发射断层扫描揭示警觉大鼠味觉的功能解剖。

• 发表时间: 2013
• 期刊: J Neurosci Res
• 影响因子: 4.2
• 作者: Kobayashi;M.;Cui;Y.L..;Sako;T.;Sasabe;T.;Mizoguchi;N.;Wada;Y.;Kataoka;Y.;Koshikawa;N.
• 通讯作者: N.

片頭痛モデル動物を用いたオピオイド受容体のPETイメージング

使用偏头痛模型动物对阿片受体进行 PET 成像

• 发表时间: 2013
• 作者: 崔翼龍;長田浩子;佐古健生;林中恵美;和田康弘;土居久志;渡辺恭良
• 通讯作者: 渡辺恭良