Anti tumor effect of micro RNA transferred by active targeting liposomes

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Lung cancer and malignant pleural mesothelioma are refractory disease. Particularly, establishment of new effective therapies are urgent business to improve prognosis of inoperable tumor with the metastasis.We have discovered microRNA (miRNA) which works inhibitory to these diseases and aimed at the establishment of active targeting liposome (lip) to accumulate to tumor cells selectively. In this study, we planned to evaluate the accumulation of the lip for the cultured tumor cells and the mouse subcutaneous tumor models for the first and the antitumor effect of the miRNA-lip the second.At first, expected enough accumulation of the lip were not observed with cells and mouse models either, but we were successful for improvement of the accumulation efficiency by improving the lip, administration condition, and model construction methods in detail. However we spent most of the period by these processes, evaluation of the lip taking into cells and developing miRNA-lip are future problems.