Development of Imaging Diagnosis for Lymphedema

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Current research aimed to establish a new active targeting liposome system for diagnosis of lymphedema, by targeting it to the lymphatic endothelial cell markers. Specific binding of the molecular targeting liposome to cultured lymphatic endothelial cells in vitro and visualization of lymphatic vessels in normal mice were demonstrated. However, we could not establish the measuring system in rat lymphedema model. As for its related technique, we could develop a new liposome encapsulated with colloidal gold which enables both light-and electron-microscopic analysis.