Establishment of risk assessment for liver resection by liver stiffness measurement with acoustic radio force impulse (ARFI)

声射电脉冲（ARFI）肝脏硬度测量建立肝切除风险评估

• 批准号: 24659605
• 负责人: HATANO Etsuro
• 金额: $ 2.41万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659605/
• 关键词: 肝切除; 肝不全; ARFI; 肝線維化; 肝切除後肝不全; liver stiffness

We aimed to assess the usefulness of liver stiffness measurement based on Acoustic Radiation Force Impulse (ARFI) for the prediction of posthepatectomy liver failure (PHLF) by prospectively analyzing clinical data of 200 patients who underwent hepatic resection. Univariate analysis revealed that liver stiffness value measured by ARFI was one of the most efficient markers in predicting PHLF as well as an excellent indicator of the grade of pathological liver fibrosis. To improve the predictive accuracy, we further performed multivariate analysis and established a novel formula that quantitatively estimates the risk of PHLF by combination of 4 significant factors: liver stiffness, platelet count, total bilirubin, and remnant liver volume rate. The validity of the formula was verified, suggesting it could be applied to clinical use in the future.

我们旨在通过前瞻性分析200例接受肝切除术患者的临床数据，评估基于声辐射力脉冲（ARFI）的肝脏硬度测量对预测术后肝功能衰竭（PHLF）的有用性。单因素分析显示，ARFI测量的肝硬度值是预测PHLF最有效的指标之一，也是病理性肝纤维化程度的良好指标。为了提高预测准确性，我们进一步进行了多变量分析，并建立了一个新的公式，通过4个重要因素的组合来定量估计PHLF的风险：肝硬度，血小板计数，总胆红素和残余肝体积率。验证了该公式的有效性，提示该公式可用于临床。

项目成果

肝硬度と血小板を基軸とした肝切除後肝不全の予測ICGに勝る術前肝機能評価因子の探究

基于肝脏硬度和血小板预测肝切除术后肝功能衰竭优于ICG的术前肝功能评估因素探索

• 发表时间: 2014
• 作者: K. Taura;Y. Koyama;K. Tanabe;G. Yamamoto;T. Nishio;E. Hatano;S. Uemoto;西尾太宏,田浦康二朗,田邉和孝,山本玄,奥田雄紀浩,瀬尾智,安近健太郎,波多野悦朗,上本伸二
• 通讯作者: 西尾太宏,田浦康二朗,田邉和孝,山本玄,奥田雄紀浩,瀬尾智,安近健太郎,波多野悦朗,上本伸二

Clinical impact of PET/CT on the management of patients with intrahepatic cholangiocarcinoma

PET/CT对肝内胆管癌治疗的临床影响

• 发表时间: 2012
• 期刊: Nihon Shokakibyo Gakkai Zasshi.
• 作者: Nakamura K;Hatano E;Miyagawa-Hayashino A;Okuno M;Koyama Y;Narita M;Seo S;Taura K;Uemoto S;Nakamura Koijro;Hatano Etsuro
• 通讯作者: Hatano Etsuro

Liver Stiffness Measurement Predicts Posthepatectomy Liver Failure (PHLF)

肝脏硬度测量可预测肝切除术后肝衰竭 (PHLF)

• 发表时间: 2014
• 作者: K. Taura;Y. Koyama;K. Tanabe;G. Yamamoto;T. Nishio;E. Hatano;S. Uemoto;西尾太宏,田浦康二朗,田邉和孝,山本玄,奥田雄紀浩,瀬尾智,安近健太郎,波多野悦朗,上本伸二;田浦康二朗,波多野悦朗,安近健太郎,瀬尾智,福光剣,上本伸二;Taura Kojiro
• 通讯作者: Taura Kojiro

Current status of hepatocellular carcinoma treatment in Japan: practical use of sorafenib (Nexavar)

日本肝癌治疗现状：索拉非尼（Nexavar）的实际应用

• DOI: 10.2165/1163023-s0-000000000-00000
• 发表时间: 2012
• 期刊: Clin Drug Investig
• 作者: Nakamura K;Hatano E;Miyagawa-Hayashino A;Okuno M;Koyama Y;Narita M;Seo S;Taura K;Uemoto S;Nakamura Koijro;Hatano Etsuro;Kokudo Norihiro
• 通讯作者: Kokudo Norihiro

肝切除後肝不全(Posthepatectomy Liver Failure; PHLF)予測における肝硬度測定の有用性

肝脏硬度测量在预测肝切除术后肝衰竭（PHLF）中的作用

• 发表时间: 2013
• 作者: K. Taura;Y. Koyama;K. Tanabe;G. Yamamoto;T. Nishio;E. Hatano;S. Uemoto;西尾太宏,田浦康二朗,田邉和孝,山本玄,奥田雄紀浩,瀬尾智,安近健太郎,波多野悦朗,上本伸二;田浦康二朗,波多野悦朗,安近健太郎,瀬尾智,福光剣,上本伸二;Taura Kojiro;西尾太宏;田浦康二朗,小山幸法,田邉和孝,山本玄,西尾太宏,波多野悦朗,上本伸二
• 通讯作者: 田浦康二朗,小山幸法,田邉和孝,山本玄,西尾太宏,波多野悦朗,上本伸二